Zhang Zheng-Wei, Yang Yang, Wu Han, Zhang Tong
Department of Hepatopancreatobiliary Surgery, Xinghua People's Hospital, Yangzhou University, Xinghua, Jiangsu, China.
Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China.
Front Bioeng Biotechnol. 2023 Sep 29;11:1278871. doi: 10.3389/fbioe.2023.1278871. eCollection 2023.
In recent years, two-dimensional (2D) layer materials have shown great potential in the field of cancer diagnosis and treatment due to their unique structural, electronic, and chemical properties. These non-spherical materials have attracted increasing attention around the world because of its widely used biological characteristics. The application of 2D layer materials like lamellar graphene, transition metal dichalcogenides (TMDs), and black phosphorus (BPs) and so on have been developed for CT/MRI imaging, serum biosensing, drug targeting delivery, photothermal therapy, and photodynamic therapy. These unique applications for tumor are due to the multi-variable synthesis of 2D materials and the structural characteristics of good ductility different from microsphere. Based on the above considerations, the application of 2D materials in cancer is mainly carried out in the following three aspects: 1) In terms of accurate and rapid screening of tumor patients, we will focus on the enrichment of serum markers and sensitive signal transformation of 2D materials; 2) The progress of 2D nanomaterials in tumor MRI and CT imaging was described by comparing the performance of traditional contrast agents; 3) In the most important aspect, we will focus on the progress of 2D materials in the field of precision drug delivery and collaborative therapy, such as photothermal ablation, sonodynamic therapy, chemokinetic therapy, etc. In summary, this review provides a comprehensive overview of the advances in the application of 2D layer materials for tumor diagnosis and treatment, and emphasizes the performance difference between 2D materials and other types of nanoparticles (mainly spherical). With further research and development, these multifunctional layer materials hold great promise in the prospects, and challenges of 2D materials development are discussed.
近年来，二维（2D）层状材料因其独特的结构、电子和化学性质，在癌症诊断与治疗领域展现出巨大潜力。这些非球形材料因其广泛的生物学特性而受到全球越来越多的关注。层状石墨烯、过渡金属二硫属化物（TMDs）和黑磷（BPs）等二维层状材料已被开发用于CT/MRI成像、血清生物传感、药物靶向递送、光热疗法和光动力疗法。这些针对肿瘤的独特应用归因于二维材料的多变量合成以及不同于微球的良好延展性的结构特征。基于上述考虑，二维材料在癌症方面的应用主要从以下三个方面展开：1）在肿瘤患者的精准快速筛查方面，我们将聚焦于血清标志物的富集以及二维材料的灵敏信号转换；2）通过比较传统造影剂的性能，阐述二维纳米材料在肿瘤MRI和CT成像方面的进展；3）在最重要的方面，我们将聚焦于二维材料在精准药物递送和协同治疗领域的进展，如光热消融、声动力疗法、化学动力学疗法等。总之，本综述全面概述了二维层状材料在肿瘤诊断与治疗应用方面的进展，并强调了二维材料与其他类型纳米颗粒（主要是球形）之间的性能差异。随着进一步的研发，这些多功能层状材料前景广阔，同时也讨论了二维材料开发所面临的挑战。
