Mostafa Niyaz, Smith Saxon D
Faculty of Medicine, The University of Sydney, Sydney, NSW, Australia.
ANU Medical School, ANU College of Health and Medicine, The Australian National University, Canberra, ACT, Australia.
Clin Cosmet Investig Dermatol. 2023 Oct 10;16:2821-2827. doi: 10.2147/CCID.S393254. eCollection 2023.
Atopic dermatitis (AD) is a chronic inflammatory skin disease that usually develops in early childhood. AD has a significant impact on quality of life and psychological health outcomes in both adults and children. There are increased reported rates of psychiatric comorbidities including anxiety, depression, ADHD and suicidal ideation compared to the general population. Primary caregivers of children with pediatric eczema and their families may also have derangements in psychological health and quality of life. A number of interventions exist for AD and address wellbeing outcomes as an important aspect of effective treatment.
A comprehensive literature search was conducted using PubMed/Medline, Embase, the Cochrane Central Register of Controlled Trials in February 2023. Published studies up to April 2023 were included related to interventions for childhood AD that included psychological health or quality of life outcomes. These interventions were stratified according to type and evidence quality.
Search strategy revealed a wide variety of interventions with demonstrated improvements in quality of life or wellbeing of patients with pediatric AD or their families. Both pharmacological and non-pharmacological interventions demonstrated effectiveness in improving disease outcomes.
A variety of both pharmacological and non-pharmacological interventions may be employed to improve psychological health outcomes in children with AD.
特应性皮炎(AD)是一种慢性炎症性皮肤病,通常在儿童早期发病。AD对成人和儿童的生活质量及心理健康结局均有重大影响。与普通人群相比,报告的包括焦虑、抑郁、注意力缺陷多动障碍(ADHD)和自杀观念在内的精神疾病共病率有所增加。患有小儿湿疹的儿童的主要照顾者及其家庭在心理健康和生活质量方面也可能出现紊乱。针对AD有多种干预措施,并且将改善健康结局作为有效治疗的一个重要方面。
2023年2月,使用PubMed/Medline、Embase、Cochrane对照试验中央注册库进行了全面的文献检索。纳入了截至2023年4月发表的与小儿AD干预措施相关的研究,这些干预措施包括心理健康或生活质量结局。这些干预措施根据类型和证据质量进行了分层。
检索策略显示了各种各样的干预措施,这些措施已证明可改善小儿AD患者或其家庭的生活质量或健康状况。药物和非药物干预措施在改善疾病结局方面均显示出有效性。
可以采用多种药物和非药物干预措施来改善AD患儿的心理健康结局。