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血压的闭环药理控制:现有系统综述

Closed-Loop Pharmacologic Control of Blood Pressure: A Review of Existing Systems.

作者信息

Baykuziyev Temur, Khan Muhammad Jaffar, Karmakar Arunabha, Baloch Muhammad Arif

机构信息

Anesthesiology and Critical Care, Hamad Medical Corporation, Doha, QAT.

出版信息

Cureus. 2023 Sep 13;15(9):e45188. doi: 10.7759/cureus.45188. eCollection 2023 Sep.

DOI:10.7759/cureus.45188
PMID:37842385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10576018/
Abstract

Blood pressure management is a critical aspect of patient care, particularly in surgical and critical care settings. Closed-loop systems, which utilize real-time data and feedback to adjust treatment interventions, have gained attention for their potential to enhance blood pressure control. This review explores the application of closed-loop systems in blood pressure management. We discuss various closed-loop approaches, including their mechanisms, benefits, and limitations. By harnessing real-time patient data and feedback, closed-loop systems can tailor interventions dynamically, thus enhancing blood pressure regulation. Additionally, we examine the integration of advanced monitoring technologies and artificial intelligence algorithms in closed-loop systems. The review highlights recent studies and their findings, emphasizing the evolving landscape of closed-loop blood pressure management across different clinical scenarios. From the perioperative period to critical care settings, closed-loop systems hold the potential to optimize patient outcomes by precisely adjusting vasopressor administration in response to continuous blood pressure fluctuations. By providing insights into the current state of closed-loop systems for blood pressure control, this review offers a comprehensive overview of their potential contributions to improved patient outcomes and future directions for research and implementation.

摘要

血压管理是患者护理的一个关键方面,在外科和重症监护环境中尤为如此。闭环系统利用实时数据和反馈来调整治疗干预措施,因其在增强血压控制方面的潜力而受到关注。本综述探讨了闭环系统在血压管理中的应用。我们讨论了各种闭环方法,包括其机制、益处和局限性。通过利用实时患者数据和反馈,闭环系统可以动态调整干预措施,从而增强血压调节。此外,我们研究了先进监测技术和人工智能算法在闭环系统中的整合。本综述突出了近期研究及其发现,强调了闭环血压管理在不同临床场景中的不断演变的格局。从围手术期到重症监护环境,闭环系统有潜力通过根据持续的血压波动精确调整血管升压药的给药来优化患者预后。通过深入了解用于血压控制的闭环系统的当前状态,本综述全面概述了它们对改善患者预后的潜在贡献以及研究和实施的未来方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b94/10576018/d6f6b24fdb5a/cureus-0015-00000045188-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b94/10576018/b78bedcbdbbc/cureus-0015-00000045188-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b94/10576018/b6baeff689d6/cureus-0015-00000045188-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b94/10576018/43e4c56657d2/cureus-0015-00000045188-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b94/10576018/93e976d69683/cureus-0015-00000045188-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b94/10576018/6f91f2ebf705/cureus-0015-00000045188-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b94/10576018/d6f6b24fdb5a/cureus-0015-00000045188-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b94/10576018/b78bedcbdbbc/cureus-0015-00000045188-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b94/10576018/b6baeff689d6/cureus-0015-00000045188-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b94/10576018/43e4c56657d2/cureus-0015-00000045188-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b94/10576018/93e976d69683/cureus-0015-00000045188-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b94/10576018/6f91f2ebf705/cureus-0015-00000045188-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b94/10576018/d6f6b24fdb5a/cureus-0015-00000045188-i06.jpg

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本文引用的文献

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A Mathematical Model for Simulation of Vasoplegic Shock and Vasopressor Therapy.一种用于模拟血管麻痹性休克和血管加压药治疗的数学模型。
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Systolic Arterial Pressure Control Using an Automated Closed-Loop System for Vasopressor Infusion during Intermediate-to-High-Risk Surgery: A Feasibility Study.在中高风险手术期间使用自动闭环系统进行血管升压药输注的收缩压控制:一项可行性研究。
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Hypotension Prediction Index Software to Prevent Intraoperative Hypotension during Major Non-Cardiac Surgery: Protocol for a European Multicenter Prospective Observational Registry (EU-HYPROTECT).
用于预防非心脏大手术术中低血压的低血压预测指数软件:欧洲多中心前瞻性观察登记研究(EU-HYPROTECT)方案
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Hypotension as a marker or mediator of perioperative organ injury: a narrative review.低血压作为围手术期器官损伤的标志物或介质:一篇叙述性评论。
Br J Anaesth. 2022 Jun;128(6):915-930. doi: 10.1016/j.bja.2022.01.012. Epub 2022 Feb 9.
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Control of Postoperative Hypotension Using a Closed-Loop System for Norepinephrine Infusion in Patients After Cardiac Surgery: A Randomized Trial.心脏手术后患者使用去甲肾上腺素输注闭环系统控制术后低血压:一项随机试验
Anesth Analg. 2022 May 1;134(5):964-973. doi: 10.1213/ANE.0000000000005888.
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In-silico analysis of closed-loop vasopressor control of phenylephrine versus norepinephrine.基于仿真模型的去甲肾上腺素与苯肾上腺素闭环血管加压素控制的比较分析。
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Computer-assisted Individualized Hemodynamic Management Reduces Intraoperative Hypotension in Intermediate- and High-risk Surgery: A Randomized Controlled Trial.计算机辅助个体化血流动力学管理减少中高危手术中的术中低血压:一项随机对照试验。
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Intraoperative Hypotension Is Associated With Adverse Clinical Outcomes After Noncardiac Surgery.术中低血压与非心脏手术后不良临床结局相关。
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