研究全身性免疫炎症指数和全身性炎症反应指数作为异维 A 酸治疗寻常痤疮的抗炎效果指标。
Investigation of systemic immune-inflammation index and systemic inflammation response index as an indicator of the anti-inflammatuary effect of isotretinoin in patients with acne vulgaris.
机构信息
Education and Research Hospital, Sakarya University, Sakarya, Turkey.
Department of Dermatology, Yenikent State Hospital, Sakarya, Turkey.
出版信息
Cutan Ocul Toxicol. 2022 Jun;41(2):174-178. doi: 10.1080/15569527.2022.2081700. Epub 2022 Jun 5.
PURPOSE
Oral isotretinoin (ISO) can effect markers of inflammation in patients with acne vulgaris. Systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) were described as novel inflammatory and prognostic biomarkers. The present study aimed to evaluate the effectiveness of SII, SIRI, and other inflammatory markers in patients with acne vulgaris who receive isotretinoin therapy.
METHODS
One hundred fifty-six patients with moderate-to-severe acne vulgaris who received at least 3 months of ISO treatment (0.5-1 mg/kg/day) and 100 healthy individuals were enrolled in the study. The medical records and laboratory findings of the participants were reviewed retrospectively. Pre-treatment and post-treatment neutrophil, lymphocyte, monocyte, and platelet counts, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), SII, SIRI, total cholesterol, LDL cholesterol, triglyceride, HDL cholesterol, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were analysed.
RESULTS
Before ISO treatment, patients with moderate-to-severe acne vulgaris had significantly higher platelet counts than healthy controls ( = 0.003). Serum total cholesterol, LDL, triglyceride, AST, and ALT increased significantly after isotretinoin treatment in patients with acne vulgaris ( < 0.001, < 0.001, < 0.001, < 0.001, = 0.029, respectively). In the follow-up of patients using ISO, a significant increase was found in platelet levels ( < 0.001). However, neutrophil, NLR, SII, and SIRI were found significantly decrease after ISO treatment ( = 0.047, = 0.038, = 0.003, = 0.001; respectively). Lymphocyte, monocyte, PLR, and MLR did not show any significant change after ISO treatment.
CONCLUSION
SII and SIRI are better parameters as an indicator of the anti-inflammatory effect of isotretinoin than other inflammatory markers.
目的
口服异维 A 酸（ISO）可影响寻常痤疮患者的炎症标志物。系统免疫炎症指数（SII）和系统炎症反应指数（SIRI）被描述为新的炎症和预后生物标志物。本研究旨在评估 SII、SIRI 和其他炎症标志物在接受异维 A 酸治疗的寻常痤疮患者中的疗效。
方法
本研究纳入了 156 例接受至少 3 个月 ISO 治疗（0.5-1mg/kg/天）的中重度寻常痤疮患者和 100 名健康对照者。回顾性分析了参与者的病历和实验室检查结果。分析了治疗前和治疗后中性粒细胞、淋巴细胞、单核细胞和血小板计数、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、单核细胞与淋巴细胞比值（MLR）、SII、SIRI、总胆固醇、LDL 胆固醇、甘油三酯、HDL 胆固醇、天门冬氨酸氨基转移酶（AST）和丙氨酸氨基转移酶（ALT）。
结果
在 ISO 治疗前，中重度寻常痤疮患者的血小板计数明显高于健康对照组（=0.003）。寻常痤疮患者在接受异维 A 酸治疗后，血清总胆固醇、LDL、甘油三酯、AST 和 ALT 均显著升高（均<0.001，均<0.001，均<0.001，均<0.001，=0.029）。在使用 ISO 的患者随访中，血小板水平显著升高（<0.001）。然而，ISO 治疗后，中性粒细胞、NLR、SII 和 SIRI 明显下降（=0.047，=0.038，=0.003，=0.001）。淋巴细胞、单核细胞、PLR 和 MLR 经 ISO 治疗后无明显变化。
结论
与其他炎症标志物相比，SII 和 SIRI 是异维 A 酸抗炎作用的更好指标。
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