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有近期重症肺炎住院史的 HIV 感染婴儿的一线抗结核药物浓度。

First-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumonia.

机构信息

University of Zambia, School of Medicine, Lusaka, Zambia.

University Teaching Hospital, Children's Hospital, Lusaka, Zambia.

出版信息

J Pediatric Infect Dis Soc. 2023 Nov 30;12(11):581-585. doi: 10.1093/jpids/piad088.

DOI:10.1093/jpids/piad088
PMID:37843384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10687595/
Abstract

Optimal antituberculosis therapy is essential for favorable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared with reference values for adults, supporting studies on increased doses of first-line TB drugs in infants.

摘要

优化抗结核治疗对于获得良好的临床结局至关重要。与成人参考值相比，接受世卫组织推荐剂量的 HIV 存活婴儿的一线抗结核药物的峰值血浆浓度较低，这支持了增加婴儿一线抗结核药物剂量的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c8/10687595/57d632539e5e/piad088_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c8/10687595/57d632539e5e/piad088_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c8/10687595/57d632539e5e/piad088_fig1.jpg

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本文引用的文献

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Int J Tuberc Lung Dis. 2023 May 1;27(5):401-407. doi: 10.5588/ijtld.22.0591.
2
Global estimates and determinants of antituberculosis drug pharmacokinetics in children and adolescents: a systematic review and individual patient data meta-analysis.全球儿童和青少年抗结核药物药代动力学的估计和决定因素：系统评价和个体患者数据荟萃分析。
Eur Respir J. 2023 Mar 9;61(3). doi: 10.1183/13993003.01596-2022. Print 2023 Mar.
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Empirical treatment against cytomegalovirus and tuberculosis in HIV-infected infants with severe pneumonia: study protocol for a multicenter, open-label randomized controlled clinical trial.
针对严重肺炎的 HIV 感染婴儿的巨细胞病毒和结核病的经验性治疗：一项多中心、开放标签、随机对照临床试验的研究方案。
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4
Pharmacokinetics of First-Line Drugs in Children With Tuberculosis, Using World Health Organization-Recommended Weight Band Doses and Formulations.初治药物在世界卫生组织推荐的体重区间剂量和剂型范围内治疗儿童结核病的药代动力学。
Clin Infect Dis. 2022 May 30;74(10):1767-1775. doi: 10.1093/cid/ciab725.
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Pharmacokinetics of antiretroviral and tuberculosis drugs in children with HIV/TB co-infection: a systematic review.抗逆转录病毒和抗结核药物在 HIV/TB 合并感染儿童中的药代动力学：系统评价。
J Antimicrob Chemother. 2020 Dec 1;75(12):3433-3457. doi: 10.1093/jac/dkaa328.
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