Nugraha Ari Satia, Firli Lilla Nur, Rani Dinar Mutia, Hidayatiningsih Ayunda, Lestari Nadya Dini, Wongso Hendris, Tarman Kustiariyah, Rahaweman Ayu Christien, Manurung Jeprianto, Ariantari Ni Putu, Papu Adelfia, Putra Masteria Yunovilsa, Pratama Antonius Nugraha Widhi, Wessjohann Ludger A, Keller Paul A
Drug Utilisation and Discovery Research Group, Faculty of Pharmacy, Universitas Jember, Jember, 68121, Indonesia.
Leibniz Institute Für Pflanzenbiochemie, Weinberg 3, 06120, Halle (Saale), Germany.
Nat Prod Bioprospect. 2023 Oct 16;13(1):38. doi: 10.1007/s13659-023-00403-1.
The archipelagic country of Indonesia is populated by the densest marine biodiversity in the world which has created strong global interest and is valued by both Indigenous and European settlements for different purposes. Nearly 1000 chemicals have been extracted and identified. In this review, a systematic data curation was employed to collate bioprospecting related manuscripts providing a comprehensive directory based on publications from 1988 to 2022. Findings with significant pharmacological activities are further discussed through a scoping data collection. This review discusses macroorganisms (Sponges, Ascidian, Gorgonians, Algae, Mangrove) and microorganism (Bacteria and Fungi) and highlights significant discoveries, including a potent microtubule stabilizer laulimalide from Hyattella sp., a prospective doxorubicin complement papuamine alkaloid from Neopetrosia cf exigua, potent antiplasmodial manzamine A from Acanthostrongylophora ingens, the highly potent anti trypanosomal manadoperoxide B from Plakortis cfr. Simplex, mRNA translation disrupter hippuristanol from Briareum sp, and the anti-HIV-1 (+)-8-hydroxymanzamine A isolated from Acanthostrongylophora sp. Further, some potent antibacterial extracts were also found from a limited biomass of bacteria cultures. Although there are currently no examples of commercial drugs from the Indonesian marine environment, this review shows the molecular diversity present and with the known understudied biodiversity, reveals great promise for future studies and outcomes.
印度尼西亚这个群岛国家拥有世界上最密集的海洋生物多样性，这引起了全球的浓厚兴趣，并且因不同目的而受到当地居民和欧洲定居者的重视。已提取并鉴定出近1000种化学物质。在本综述中，我们采用系统的数据整理方法来整理与生物勘探相关的手稿，基于1988年至2022年的出版物提供了一份全面的目录。通过范围界定数据收集，进一步讨论了具有显著药理活性的研究结果。本综述讨论了大型生物（海绵、海鞘、柳珊瑚、藻类、红树林）和微生物（细菌和真菌），并突出了重大发现，包括从Hyattella sp.中提取的一种有效的微管稳定剂劳利马利德、从Neopetrosia cf exigua中提取的一种有望替代阿霉素的巴布胺生物碱、从Acanthostrongylophora ingens中提取的强效抗疟原虫曼扎明A、从Plakortis cfr. Simplex中提取的高效抗锥虫药马纳多过氧化物B、从Briareum sp.中提取的mRNA翻译破坏剂马栗树皮醇，以及从Acanthostrongylophora sp.中分离出的抗HIV-1（+）-8-羟基曼扎明A。此外，还从有限的细菌培养物生物量中发现了一些强效抗菌提取物。尽管目前还没有来自印度尼西亚海洋环境的商业药物实例，但本综述展示了现有的分子多样性，以及已知但研究不足的生物多样性，揭示了未来研究和成果的巨大潜力。
