Current advances, challenges and strategies for enhancing the biodegradation of plastic waste.

Due to its highly recalcitrant nature, the growing accumulation of plastic waste is becoming an urgent global problem. Biodegradation is one of the best possible approaches for the treatment of plastic waste in an environmentally friendly manner, but our current knowledge on the underlying mechanisms, as well as strategies for the development and enhancement of plastic biodegradation are still limited. This review aims to provide an updated and comprehensive overview of current research on plastic waste biodegradation, focusing on enhancement strategies with ongoing research significance, including the mining of highly efficient plastic-degrading microorganisms/enzymes, utilization of synergistic additives, novel pretreatment approaches, modification via molecular engineering, and construction of bacterial/enzyme consortia systems. Studying these strategies can (i) enrich the high-performance microbial/enzymes toolbox for plastic degradation, (ii) provide methods for recycling and upgrading plastics, as well as (iii) enable further molecular modification and functional optimization of plastic-degrading enzymes to realize economically viable biodegradation of plastics. To the best of our knowledge, this is the first review to discuss in detail strategies to enhance biodegradation of plastics. Finally, some recommendations for future research on plastic biodegradation are listed, hoping to provide the best direction for tackling the plastic waste dilemma in the future.