Faculty of Physical Culture, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland; Changsha Commerce & Tourism College, 410116, Changsha, China.
School of Management, Beijing Sport University, 100084, Beijing, China.
Exp Gerontol. 2023 Nov;183:112310. doi: 10.1016/j.exger.2023.112310. Epub 2023 Oct 20.
Postmenopausal women affected by overweight and obesity are susceptible to a variety of diseases due to inflammation. Exercise may reduce the risk of disease by attenuating low-grade chronic inflammation.
We conducted a systematic review and meta-analysis to investigate the effects of exercise on inflammatory markers in postmenopausal women struggling with overweight and obesity.
Literature as of May 2023 was searched from databases such as Cochrane, Embase, Pubmed, Web of Science, and EBSCO and English-language randomized controlled trials (RCTs) that meet the inclusion criteria were selected. Studies were included based on the following criteria: (A) Written in English; (B) RCTs; (C) Postmenopausal women impacted by overweight and obesity as research objects; (D) Outcome measurements include CRP, TNF-α, IL-6, and adiponectin; (E) Duration of the exercise intervention is eight weeks.
A total of 34 articles and 2229 participants were included. Exercise can significantly reduce the level of C-reactive protein (CRP) (MD: -0.59, 95 % CI: -0.87 to -0.31, p < 0.00001), tumor necrosis factor-α (TNF-α) (MD: -0.65, 95 % CI: -0.94 to -0.35, p < 0.00001), interleukin-6 (IL-6) (MD: -0.48, 95 % CI: -0.75 to -0.21, p < 0.00001), and exercise can significantly increase the level of adiponectin (MD: 0.33, 95 % CI: 0.02 to 0.65, p = 0.04) in women impacted by overweight and obesity.
These results suggest that exercise may be an effective intervention for reducing pro-inflammatory markers and increasing adiponectin in postmenopausal women impacted by overweight and obesity. The findings may provide clinicians and healthcare professionals with insights into the implementation of exercise programs for postmenopausal women living with overweight and obesity.
超重和肥胖的绝经后妇女由于炎症而易患多种疾病。运动通过减轻低度慢性炎症，可能降低疾病风险。
我们进行了一项系统评价和荟萃分析，以研究运动对超重和肥胖绝经后妇女炎症标志物的影响。
截至 2023 年 5 月，从 Cochrane、Embase、Pubmed、Web of Science 和 EBSCO 等数据库中检索文献，并选择符合纳入标准的英语随机对照试验（RCT）。研究纳入标准如下：（A）用英语书写；（B）RCT；（C）超重和肥胖绝经后妇女为研究对象；（D）结局测量包括 CRP、TNF-α、IL-6 和脂联素；（E）运动干预持续时间为八周。
共纳入 34 篇文章和 2229 名参与者。运动可显著降低 C 反应蛋白（CRP）水平（MD：-0.59，95%CI：-0.87 至-0.31，p<0.00001）、肿瘤坏死因子-α（TNF-α）（MD：-0.65，95%CI：-0.94 至-0.35，p<0.00001）、白细胞介素-6（IL-6）（MD：-0.48，95%CI：-0.75 至-0.21，p<0.00001），运动可显著增加脂联素水平（MD：0.33，95%CI：0.02 至 0.65，p=0.04）。
这些结果表明，运动可能是降低超重和肥胖绝经后妇女促炎标志物和增加脂联素的有效干预措施。这些发现可能为临床医生和医疗保健专业人员提供有关实施超重和肥胖绝经后妇女运动计划的见解。
