Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China; Irish Centre for Vascular Biology, School of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland, Ireland.
Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Environ Pollut. 2023 Dec 15;339:122756. doi: 10.1016/j.envpol.2023.122756. Epub 2023 Oct 14.
The development and outcome of inflammatory diseases are associated with genetic and lifestyle factors, which include chemical and nonchemical stressors. Persistent organic pollutants (POPs) are major groups of chemical stressors. For example, dioxin-like polychlorinated biphenyls (PCBs), per- and polyfluoroalkyl substances (PFASs), and polybrominated diphenyl ethers (PBDEs) are closely associated with the incidence of inflammatory diseases. The pathology of environmental chemical-mediated inflammatory diseases is complex and may involve disturbances in multiple organs, including the gut, liver, brain, vascular tissues, and immune systems. Recent studies suggested that diet-derived nutrients (e.g., phytochemicals, vitamins, unsaturated fatty acids, dietary fibers) could modulate environmental insults and affect disease development, progression, and outcome. In this article, mechanisms of environmental pollutant-induced inflammation and cardiometabolic diseases are reviewed, focusing on multi-organ interplays and highlighting recent advances in nutritional strategies to improve the outcome of cardiometabolic diseases associated with environmental exposures. In addition, advanced system biology approaches are discussed, which present unique opportunities to unveil the complex interactions among multiple organs and to fuel the development of precision intervention strategies in exposed individuals.
炎症性疾病的发生和发展与遗传和生活方式因素有关，其中包括化学和非化学应激源。持久性有机污染物（POPs）是化学应激源的主要类别。例如，类二恶英多氯联苯（PCBs）、全氟和多氟烷基物质（PFASs）以及多溴联苯醚（PBDEs）与炎症性疾病的发病率密切相关。环境化学介导的炎症性疾病的病理十分复杂，可能涉及多个器官的紊乱，包括肠道、肝脏、大脑、血管组织和免疫系统。最近的研究表明，饮食来源的营养素（例如植物化学物质、维生素、不饱和脂肪酸、膳食纤维）可以调节环境刺激并影响疾病的发展、进展和结果。本文综述了环境污染物引起的炎症和心血管代谢疾病的机制，重点关注多器官相互作用，并强调了营养策略在改善与环境暴露相关的心血管代谢疾病方面的最新进展。此外，还讨论了先进的系统生物学方法，这些方法为揭示多个器官之间的复杂相互作用以及为暴露个体开发精准干预策略提供了独特的机会。
