Department of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Tongzipo Road, Changsha, Hunan, 410013, P. R. China.
Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, P. R. China.
Adv Sci (Weinh). 2023 Nov;10(33):e2303767. doi: 10.1002/advs.202303767. Epub 2023 Oct 16.
Patients with metabolic syndrome (MetS) undergoing surgery are at high risk of developing peritoneal adhesions and other severe postoperative complications. However, the single shielding function and absence of physiological activity render conventional methods less useful in preventing adhesions in patients with MetS. To address this challenge, a convenient method is introduced for developing a novel tissue-adhesive hydrogel called oxidized dextran-metformin (ODE-ME) via Schiff base linkages. This injectable ODE-ME hydrogel exhibits excellent tissue-adhesive properties and various physiological functions, particularly enhanced antibacterial effects. Furthermore, in vivo experiments demonstrate that the hydrogel can effectively alleviate hyperglycemia, reduce excessive inflammation, and improve fibrinolytic activity in MetS mice, thereby preventing adhesions and promoting incisional healing. The hydrogel concurrently isolates injured tissues and lowers the blood glucose levels immediately after surgery in mice. Therefore, the ODE-ME hydrogel functions as a multifunctional barrier material and has potential for preventing postoperative peritoneal adhesions in patients with MetS in clinical settings.
患有代谢综合征（MetS）的患者在接受手术时，发生腹膜粘连和其他严重术后并发症的风险很高。然而，传统方法的单一屏蔽功能和缺乏生理活性使得它们在预防 MetS 患者粘连方面效果不佳。为了应对这一挑战，我们引入了一种方便的方法，通过希夫碱键合开发了一种新型组织粘合剂水凝胶，称为氧化葡聚糖-二甲双胍（ODE-ME）。这种可注射的 ODE-ME 水凝胶具有优异的组织粘合性能和多种生理功能，特别是增强的抗菌作用。此外，体内实验表明，该水凝胶可有效缓解高血糖，减少过度炎症，并改善 MetS 小鼠的纤维蛋白溶解活性，从而防止粘连并促进切口愈合。水凝胶在手术后立即隔离受损组织并降低小鼠的血糖水平。因此，ODE-ME 水凝胶作为一种多功能屏障材料，具有预防 MetS 患者术后腹膜粘连的潜力，有望在临床中得到应用。
