MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, P. R. China.
Biomedical Microdevices Research Laboratory, Shenzhen Institutes of Advanced Technology, The Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen, 518055, P. R. China.
Adv Mater. 2023 May;35(18):e2212302. doi: 10.1002/adma.202212302. Epub 2023 Mar 17.
Reducing the swelling of tissue-adhesive hydrogels is crucial for maintaining stable tissue adhesion and inhibiting tissue inflammation. However, reported strategies for reducing swelling always result in a simultaneous decrease in the tissue adhesive strength of the hydrogel. Furthermore, once the covalent bonds break in the currently reported hydrogels, they cannot be rebuilt, and the hydrogel loses its tissue adhesive ability. In this work, a nonswelling hydrogel (named as "PAACP") possessing regenerable high tissue adhesion is synthesized by copolymerizing and crosslinking poly(vinyl butyral) with acrylic acid, gelatin, and chitosan-grafted N-acetyl-l-cysteine. The tissue adhesive strength of the obtained PAACP reaches 211.4 kPa, which is approximately ten times higher than that of the reported nonswelling hydrogels, and the hydrogel can be reused for multiple cycles. The as-prepared hydrogel shows great potential in soft bioelectronics, as muscle fatigue is successfully monitored via the electrode array and strain sensor integrated on PAACP substrates. The success of these bioelectronics offers potential applicability in the long-term diagnosis of muscle-related health conditions and prosthetic manipulations.
减少组织黏附水凝胶的肿胀对于维持稳定的组织黏附和抑制组织炎症至关重要。然而，据报道，减少肿胀的策略总是会导致水凝胶的组织黏附强度同时降低。此外，一旦目前报道的水凝胶中的共价键断裂，它们就无法重建，水凝胶会失去组织黏附能力。在这项工作中，通过共聚和交联聚（丁基乙烯基）与丙烯酸、明胶和接枝 N-乙酰-L-半胱氨酸的壳聚糖合成了一种不可溶胀的水凝胶（命名为“PAACP”），具有可再生的高组织黏附性。所得到的 PAACP 的组织黏附强度达到 211.4 kPa，大约是报道的不可溶胀水凝胶的十倍，并且该水凝胶可以重复使用多个循环。所制备的水凝胶在软生物电子学中具有很大的应用潜力，因为通过集成在 PAACP 基底上的电极阵列和应变传感器成功监测了肌肉疲劳。这些生物电子学的成功为肌肉相关健康状况和假肢操作的长期诊断提供了潜在的适用性。
