Kalva Praneeth, Akram Rubeel, Mekala Priya, Patel Monica, Suresh Sruthi, Kooner Karanjit S
Department of Ophthalmology, University of Texas at Southwestern Medical Center, Dallas, TX, USA.
Department of Ophthalmology, Veteran Affairs North Texas Health Care Medical Center, Dallas, TX, USA.
Adv Ophthalmol Pract Res. 2023 May 12;3(3):119-125. doi: 10.1016/j.aopr.2023.05.002. eCollection 2023 Aug-Sep.
To quantitatively measure and compare the vascular morphology in healthy eyes and eyes with primary open-angle glaucoma (POAG) using optical coherence tomography angiography (OCTA) scans.
This is a retrospective and cross-sectional study which include healthy individuals and individuals with POAG that underwent OCTA imaging at an academic center's glaucoma clinic. We analyzed OCTA scans of the macula and optic nerve head (ONH) of one eye from each subject to quantitatively measure vessel density (VD), vessel length density (VLD), and branchpoint density (BPD). We compared these 3 parameters between the healthy and POAG groups and used logistic regression classification models to determine their diagnostic value in differentiating healthy and glaucomatous eyes.
We included 49 healthy subjects and 49 subjects with POAG. After age-adjusted analysis, the parameters of VD, VLD, and BPD were significantly reduced in eyes with POAG ( < 0.001) in all scan layers and most significantly around the ONH. The parameter with the best performances were radial peripapillary capillary (RPC) VD [AUC (areas under the curve): 0.939 (0.891, 0.987)] which had statistically higher performances ( < 0.05) than parameters in the superficial or deep layers. All 3 parameters in the RPC layer had statistically similar performances.
We found that VD, VLD, and BPD were reduced in glaucomatous eyes. The morphologic parameters of VLD and BPD had similar performances to the traditional parameter of VD in RPC layers. Our results suggest that vascular morphology parameters may provide additional value in the diagnosis and evaluation of glaucoma.
使用光学相干断层扫描血管造影（OCTA）扫描定量测量并比较健康眼睛和原发性开角型青光眼（POAG）患者眼睛的血管形态。
这是一项回顾性横断面研究，纳入了在学术中心青光眼诊所接受OCTA成像的健康个体和POAG患者。我们分析了每个受试者一只眼睛的黄斑和视神经乳头（ONH）的OCTA扫描图像，以定量测量血管密度（VD）、血管长度密度（VLD）和分支点密度（BPD）。我们比较了健康组和POAG组之间的这三个参数，并使用逻辑回归分类模型来确定它们在区分健康眼睛和青光眼性眼睛方面的诊断价值。
我们纳入了49名健康受试者和49名POAG患者。经过年龄调整分析后，POAG患者眼睛的VD、VLD和BPD参数在所有扫描层均显著降低（P<0.001），在ONH周围最为显著。表现最佳的参数是放射状视乳头周围毛细血管（RPC）VD [曲线下面积（AUC）：0.939（0.891，0.987）]，其表现统计学上高于表层或深层的参数（P<0.05）。RPC层的所有三个参数表现统计学上相似。
我们发现青光眼性眼睛的VD、VLD和BPD降低。VLD和BPD的形态学参数在RPC层与传统的VD参数表现相似。我们的结果表明，血管形态学参数可能在青光眼的诊断和评估中提供额外价值。
