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非药物干预对儿童严重急性呼吸道感染的影响：来自国家监测数据库。

Impact of Nonpharmacological Interventions on Severe Acute Respiratory Infections in Children: From the National Surveillance Database.

机构信息

Department of Pediatrics, Korea University Guro Hospital, Seoul, Korea.

Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea.

出版信息

J Korean Med Sci. 2023 Oct 16;38(40):e311. doi: 10.3346/jkms.2023.38.e311.

DOI:10.3346/jkms.2023.38.e311
PMID:37846785
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10578990/
Abstract

BACKGROUND

Nonpharmacological interventions (NPIs) reduce the incidence of respiratory infections. After NPIs imposed during the coronavirus disease 2019 pandemic ceased, respiratory infections gradually increased worldwide. However, few studies have been conducted on severe respiratory infections requiring hospitalization in pediatric patients. This study compares epidemiological changes in severe respiratory infections during pre-NPI, NPI, and post-NPI periods in order to evaluate the effect of that NPI on severe respiratory infections in children.

METHODS

We retrospectively studied data collected at 13 Korean sentinel sites from January 2018 to October 2022 that were lodged in the national Severe Acute Respiratory Infections (SARIs) surveillance database.

RESULTS

A total of 9,631 pediatric patients were admitted with SARIs during the pre-NPI period, 579 during the NPI period, and 1,580 during the post-NPI period. During the NPI period, the number of pediatric patients hospitalized with severe respiratory infections decreased dramatically, thus from 72.1 per 1,000 to 6.6 per 1,000. However, after NPIs ceased, the number increased to 22.8 per 1,000. During the post-NPI period, the positive test rate increased to the level noted before the pandemic.

CONCLUSION

Strict NPIs including school and daycare center closures effectively reduced severe respiratory infections requiring hospitalization of children. However, childcare was severely compromised. To prepare for future respiratory infections, there is a need to develop a social consensus on NPIs that are appropriate for children.

摘要

背景

非药物干预（NPIs）可降低呼吸道感染的发生率。在 2019 年冠状病毒病（COVID-19）大流行期间实施 NPIs 后，全球范围内呼吸道感染逐渐增加。然而，针对需要住院治疗的儿科患者严重呼吸道感染的研究较少。本研究比较了 NPIs 前、NPIs 中和 NPIs 后时期严重呼吸道感染的流行病学变化，以评估 NPIs 对儿童严重呼吸道感染的影响。

方法

我们回顾性研究了 2018 年 1 月至 2022 年 10 月在韩国 13 个哨点收集的数据，这些数据被纳入国家严重急性呼吸道感染（SARI）监测数据库。

结果

在 NPIs 前时期，共有 9631 例儿科患者因 SARI 住院，NPIs 时期为 579 例，NPIs 后时期为 1580 例。在 NPIs 时期，因严重呼吸道感染住院的儿科患者数量急剧下降，从每 1000 人 72.1 例降至每 1000 人 6.6 例。然而，NPIs 停止后，该数字增加到每 1000 人 22.8 例。在 NPIs 后时期，阳性检出率增加到大流行前的水平。

结论

严格的 NPIs 包括学校和日托中心关闭可有效降低儿童因严重呼吸道感染住院的人数。然而，儿童保育受到了严重影响。为了为未来的呼吸道感染做好准备，有必要就适合儿童的 NPIs 达成社会共识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6152/10578990/501c58db24ca/jkms-38-e311-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6152/10578990/937757db5b71/jkms-38-e311-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6152/10578990/e745d659dfc5/jkms-38-e311-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6152/10578990/501c58db24ca/jkms-38-e311-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6152/10578990/937757db5b71/jkms-38-e311-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6152/10578990/e745d659dfc5/jkms-38-e311-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6152/10578990/501c58db24ca/jkms-38-e311-g003.jpg

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