Parab P V, Ritschel W A, Coyle D E, Denson D D
Methods Find Exp Clin Pharmacol. 1987 Apr;9(4):251-60.
Pharmacokinetic evaluation was performed using RESID, NONLIN84, KINPAK and AUC-RPP programs for a crossover hydromorphone study involving I.V., P.O. and rectal administration in humans. It was observed that when the curve fitting was difficult by using compartment model dependent methods, pharmacokinetic parameters could still be estimated by compartment model independent analysis.
在一项涉及人体静脉注射、口服和直肠给药的氢吗啡酮交叉研究中，使用RESID、NONLIN84、KINPAK和AUC-RPP程序进行了药代动力学评估。观察到，当使用依赖房室模型的方法进行曲线拟合困难时，仍可通过非房室模型分析来估算药代动力学参数。
