School of Medical Imaging, Weifang Medical University, Weifang, 261053, Shandong, China.
Department of Radiology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Abdom Radiol (NY). 2024 Feb;49(2):560-574. doi: 10.1007/s00261-023-04062-1. Epub 2023 Oct 17.
Diabetic kidney disease (DKD) is a significant healthcare burden worldwide that substantially increases the risk of kidney failure and cardiovascular events. To reduce the prevalence of DKD, extensive research is being conducted to determine the risk factors and consequently implement early interventions. Patients with type 2 diabetes mellitus (T2DM) are more likely to be obese. Abdominal adiposity is associated with a greater risk of kidney damage than general obesity. Abdominal adipose tissue can be divided into different fat depots according to the location and function, including visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), perirenal adipose tissue (PAT), and renal sinus adipose tissue (RSAT), which can be accurately measured by radiology techniques, such as computed tomography (CT) and magnetic resonance imaging (MRI). Abdominal fat depots may affect the development of DKD through different mechanisms, and radiologic abdominal adipose characteristics may serve as imaging indicators of DKD risk. This review will first describe the CT/MRI-based assessment of abdominal adipose depots and subsequently describe the current studies on abdominal adipose tissue and DKD development, as well as the underlying mechanisms in patients of T2DM with DKD.
糖尿病肾病（DKD）是全球范围内的一项重大医疗保健负担，它大大增加了肾衰竭和心血管事件的风险。为了降低 DKD 的患病率，正在进行广泛的研究以确定风险因素，从而实施早期干预。2 型糖尿病（T2DM）患者更有可能肥胖。腹部肥胖与肾脏损害的风险增加有关，而不是一般肥胖。腹部脂肪组织可根据位置和功能分为不同的脂肪储存库，包括内脏脂肪组织（VAT）、皮下脂肪组织（SAT）、肾周脂肪组织（PAT）和肾窦脂肪组织（RSAT），这些脂肪储存库可以通过放射学技术（如计算机断层扫描（CT）和磁共振成像（MRI））准确测量。腹部脂肪储存库可能通过不同的机制影响 DKD 的发展，放射学腹部脂肪特征可以作为 DKD 风险的影像学指标。本综述将首先描述基于 CT/MRI 的腹部脂肪储存库评估，然后描述当前关于腹部脂肪组织与 DKD 发展的研究，以及 T2DM 合并 DKD 患者的潜在机制。
