Dougherty P M, Harper C, Dafny N
Life Sci. 1986 Dec 8;39(23):2191-7. doi: 10.1016/0024-3205(86)90396-6.
An interconnection between the immune and the central nervous systems has been suggested by investigators studying the actions of several types of immune modifying agents and procedures upon opiate related phenomena. These studies have included the effects of altering immune system function by administration of either alpha-interferon, cyclosporine or radiation exposure upon naloxone-precipitated opiate withdrawal and upon opioid antinociceptive effects. The present study extends these earlier investigations by examining the effect of immune modulation upon opiate induced hypothermia. The results demonstrate that interferon and cyclosporine have no effects on baseline temperature or morphine induced hypothermia, while irradiation exposure elicits hyperthermia without affecting morphine-induced hypothermia. Finally, neither cyclosporine nor irradiation affect the development of tolerance to morphine induced hypothermia, while a single injection of the immune system modifier interferon was able to prevent the development of such tolerance. These observations suggest that yet another opiate-related phenomenon may be regulated at least in part by the immune system. These results together with our previous findings are further evidence of a link between the immune system and the CNS mediated through the opioid system. In addition, these studies further support our earlier hypothesis that "Interferon" is one of the endogenous substances which serves to prevent the development of tolerance and dependence to endogenous opioids.
研究几种免疫调节药物及程序作用于阿片类相关现象的研究人员提出，免疫系统与中枢神经系统之间存在相互联系。这些研究包括通过给予α干扰素、环孢素或进行辐射暴露来改变免疫系统功能，观察其对纳洛酮诱发的阿片戒断反应以及阿片类药物镇痛作用的影响。本研究通过检测免疫调节对阿片类药物诱发的体温过低的影响，扩展了这些早期研究。结果表明，干扰素和环孢素对基础体温或吗啡诱发的体温过低没有影响，而辐射暴露会引发体温过高，但不影响吗啡诱发的体温过低。最后，环孢素和辐射均不影响对吗啡诱发体温过低的耐受性的形成，而单次注射免疫系统调节剂干扰素能够阻止这种耐受性的形成。这些观察结果表明，至少部分与阿片类药物相关的现象可能受免疫系统调节。这些结果与我们之前的发现共同进一步证明了免疫系统与通过阿片系统介导的中枢神经系统之间存在联系。此外，这些研究进一步支持了我们早期的假设，即“干扰素”是一种内源性物质，可防止对内源性阿片类药物产生耐受性和依赖性。
