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脱水的诊断与管理新进展

New horizons in the diagnosis and management of dehydration.

机构信息

Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.

Falls and Syncope Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

出版信息

Age Ageing. 2023 Oct 2;52(10). doi: 10.1093/ageing/afad193.

Abstract

Hydration is a fundamental aspect of clinical practice and yet it is an under-researched topic, particularly in older people, leading to many areas of uncertainty. There are two types of dehydration; hypertonic, which is a water deficit, and isotonic, which is a deficit of both water and salt. Individual clinical signs and bedside tests are poor diagnostic tools, making dehydration difficult to identify. However, the diagnostic value of a holistic clinical approach is not known. The gold-standard clinical test for dehydration is serum osmolality, but this cannot diagnose isotonic dehydration and may delay diagnosis in acute situations. Salivary osmolality point-of-care testing is a promising and rapid new diagnostic test capable of detecting both hypertonic and isotonic dehydration in older people, but further evidence to support its clinical utility is needed. Daily fluid requirements may be less than previously thought in adults, but the evidence specific to older people remains limited. Hydration via the subcutaneous route is safer and easier to initiate than the intravenous route but is limited by infusion speed and volume. Prompting older adults more frequently to drink, offering a wider selection of drinks and using drinking vessels with particular features can result in small increases in oral intake in the short-term. The ongoing clinically-assisted hydration at end of life (CHELsea II) trial will hopefully provide more evidence for the emotive issue of hydration at the end of life.

摘要

水合作用是临床实践的一个基本方面,但它是一个研究不足的课题,特别是在老年人中,导致许多领域存在不确定性。脱水有两种类型:高渗性,即缺水;等渗性,即缺水和缺盐。个体临床症状和床边检查是很差的诊断工具,使脱水难以识别。然而,整体临床方法的诊断价值尚不清楚。脱水的金标准临床检测是血清渗透压,但它不能诊断等渗性脱水,在急性情况下可能会延迟诊断。唾液渗透压即时检测是一种有前途的快速新诊断测试,能够检测老年人的高渗性和等渗性脱水,但需要更多证据来支持其临床实用性。成年人的每日液体需求可能低于以前的想法,但针对老年人的证据仍然有限。通过皮下途径补液比静脉途径更安全、更容易启动,但受到输注速度和容量的限制。更频繁地提醒老年人喝水,提供更多种类的饮料,并使用具有特殊功能的饮水容器,可以在短期内使口服摄入量略有增加。正在进行的生命末期临床辅助水化(CHELsea II)试验有望为生命末期水化这一充满情感的问题提供更多证据。

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