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本文引用的文献

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Variation in human water turnover associated with environmental and lifestyle factors.人类水周转率的变化与环境和生活方式因素有关。
Science. 2022 Nov 25;378(6622):909-915. doi: 10.1126/science.abm8668. Epub 2022 Nov 24.
2
Clinically assisted hydration in patients in the last days of life ('CHELsea II' trial): a cluster randomised trial.在生命末期患者中临床辅助补液(CHELsea II 试验):一项集群随机试验。
BMJ Open. 2022 Nov 23;12(11):e068846. doi: 10.1136/bmjopen-2022-068846.
3
Absorption rate of subcutaneously infused fluid in ill multimorbid older patients.皮下输注液体在多病老年患者中的吸收率。
PLoS One. 2022 Oct 10;17(10):e0275783. doi: 10.1371/journal.pone.0275783. eCollection 2022.
4
Interventions to Improve Hydration in Older Adults: A Systematic Review and Meta-Analysis.干预措施以改善老年人的水分摄入:系统评价和荟萃分析。
Nutrients. 2021 Oct 18;13(10):3640. doi: 10.3390/nu13103640.
5
Harms and Benefits of Subcutaneous Hydration in Older Patients: Systematic Review and Meta-Analysis.老年患者皮下补液的危害和益处:系统评价和荟萃分析。
J Am Geriatr Soc. 2020 Dec;68(12):2937-2946. doi: 10.1111/jgs.16707. Epub 2020 Aug 15.
6
Chronic Dehydration in Nursing Home Residents.养老院居民的慢性脱水。
Nutrients. 2020 Nov 20;12(11):3562. doi: 10.3390/nu12113562.
7
Behavioral Mimicry as a Strategy to Increase Drinking Behaviors in Older Adults.行为模仿作为增加老年人饮酒行为的策略。
Am J Speech Lang Pathol. 2020 Aug 4;29(3):1640-1649. doi: 10.1044/2020_AJSLP-19-00184. Epub 2020 Jun 24.
8
Diagnostic efficacy of bedside ultrasound to detect dehydration in older patients attending an emergency care unit.床边超声对急诊科老年患者脱水情况的诊断效能
Z Gerontol Geriatr. 2021 Mar;54(2):130-135. doi: 10.1007/s00391-020-01711-8. Epub 2020 Feb 27.
9
'I've never drunk very much water and I still don't, and I see no reason to do so': a qualitative study of the views of community-dwelling older people and carers on hydration in later life.“我从来没有喝过很多水,现在也不喝,我觉得没有理由这样做”:一项关于社区居住的老年人及其照顾者对晚年水合作用看法的定性研究。
Age Ageing. 2019 Dec 1;49(1):111-118. doi: 10.1093/ageing/afz141.
10
A multidisciplinary consensus on dehydration: definitions, diagnostic methods and clinical implications.多学科共识脱水:定义、诊断方法和临床意义。
Ann Med. 2019 May-Jun;51(3-4):232-251. doi: 10.1080/07853890.2019.1628352. Epub 2019 Jun 17.

脱水的诊断与管理新进展

New horizons in the diagnosis and management of dehydration.

机构信息

Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.

Falls and Syncope Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

出版信息

Age Ageing. 2023 Oct 2;52(10). doi: 10.1093/ageing/afad193.

DOI:10.1093/ageing/afad193
PMID:37847795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10581537/
Abstract

Hydration is a fundamental aspect of clinical practice and yet it is an under-researched topic, particularly in older people, leading to many areas of uncertainty. There are two types of dehydration; hypertonic, which is a water deficit, and isotonic, which is a deficit of both water and salt. Individual clinical signs and bedside tests are poor diagnostic tools, making dehydration difficult to identify. However, the diagnostic value of a holistic clinical approach is not known. The gold-standard clinical test for dehydration is serum osmolality, but this cannot diagnose isotonic dehydration and may delay diagnosis in acute situations. Salivary osmolality point-of-care testing is a promising and rapid new diagnostic test capable of detecting both hypertonic and isotonic dehydration in older people, but further evidence to support its clinical utility is needed. Daily fluid requirements may be less than previously thought in adults, but the evidence specific to older people remains limited. Hydration via the subcutaneous route is safer and easier to initiate than the intravenous route but is limited by infusion speed and volume. Prompting older adults more frequently to drink, offering a wider selection of drinks and using drinking vessels with particular features can result in small increases in oral intake in the short-term. The ongoing clinically-assisted hydration at end of life (CHELsea II) trial will hopefully provide more evidence for the emotive issue of hydration at the end of life.

摘要

水合作用是临床实践的一个基本方面,但它是一个研究不足的课题,特别是在老年人中,导致许多领域存在不确定性。脱水有两种类型:高渗性,即缺水;等渗性,即缺水和缺盐。个体临床症状和床边检查是很差的诊断工具,使脱水难以识别。然而,整体临床方法的诊断价值尚不清楚。脱水的金标准临床检测是血清渗透压,但它不能诊断等渗性脱水,在急性情况下可能会延迟诊断。唾液渗透压即时检测是一种有前途的快速新诊断测试,能够检测老年人的高渗性和等渗性脱水,但需要更多证据来支持其临床实用性。成年人的每日液体需求可能低于以前的想法,但针对老年人的证据仍然有限。通过皮下途径补液比静脉途径更安全、更容易启动,但受到输注速度和容量的限制。更频繁地提醒老年人喝水,提供更多种类的饮料,并使用具有特殊功能的饮水容器,可以在短期内使口服摄入量略有增加。正在进行的生命末期临床辅助水化(CHELsea II)试验有望为生命末期水化这一充满情感的问题提供更多证据。