Gormly A A, Smith P S, Seymour A E, Clarkson A R, Woodroffe A J
Am J Pathol. 1981 Jul;104(1):50-4.
Lewis rats rendered cirrhotic by the administration of carbon tetrachloride developed mesangial and glomerular capillary wall deposits of immunoglobulins (especially IgA) and complement. These rats also had circulating immune complexes and markedly elevated serum IgA concentrations. The model suggests that defective hepatic sequestration of circulating IgA polymers and immune complexes may be responsible for the glomerular deposits. A similar mechanism may account for the high incidence of glomerulonephritis in patients with alcoholic cirrhosis.
通过给予四氯化碳而导致肝硬化的Lewis大鼠出现了系膜和肾小球毛细血管壁免疫球蛋白（尤其是IgA）和补体沉积。这些大鼠还存在循环免疫复合物，且血清IgA浓度显著升高。该模型表明，循环IgA聚合物和免疫复合物的肝脏清除功能缺陷可能是肾小球沉积物的原因。类似的机制可能解释酒精性肝硬化患者肾小球肾炎的高发病率。
