Department of Pediatrics, Masonic Cancer Center, University of Minnesota - Twin Cities, 515 Delaware St SE, Minneapolis, MN, 55455, USA.
Division of Epidemiology & Clinical Research, Department of Pediatrics, University of Minnesota - Twin Cities, 420 Delaware St SE MMC 715, Minneapolis, MN, 55455, USA.
BMC Res Notes. 2023 Oct 17;16(1):275. doi: 10.1186/s13104-023-06515-8.
In epidemiological and experimental research, high folic acid intake has been demonstrated to accelerate tumor development among populations with genetic and/or molecular susceptibility to cancer. Neurofibromatosis type 1 (NF1) is a common autosomal dominant disorder predisposing affected individuals to tumorigenesis, including benign plexiform neurofibromas; however, understanding of factors associated with tumor risk in NF1 patients is limited. Therefore, we investigated whether pregestational folic acid intake modified plexiform-like peripheral nerve sheath tumor risk in a transgenic NF1 murine model.
We observed no significant differences in overall survival according to folate group. Relative to controls (180 days), median survival did not statistically differ in deficient (174 days, P = 0.56) or supplemented (177 days, P = 0.13) folate groups. Dietary folate intake was positively associated with RBC folate levels at weaning, (P = 0.023, 0.0096, and 0.0006 for deficient vs. control, control vs. supplemented, and deficient vs. supplemented groups, respectively). Dorsal root ganglia (DRG), brachial plexi, and sciatic nerves were assessed according to folate group. Mice in the folate deficient group had significantly more enlarged DRG relative to controls (P = 0.044), but no other groups statistically differed. No significant differences for brachial plexi or sciatic nerve enlargement were observed according to folate status.
在流行病学和实验研究中，高叶酸摄入已被证明会加速具有遗传和/或分子致癌易感性的人群的肿瘤发展。1 型神经纤维瘤病（NF1）是一种常见的常染色体显性遗传病，使受影响的个体易发生肿瘤形成，包括良性丛状神经纤维瘤；然而，对 NF1 患者肿瘤风险相关因素的理解有限。因此，我们研究了在 NF1 转基因小鼠模型中，孕前叶酸摄入是否改变了丛状样周围神经鞘瘤的风险。
我们没有观察到叶酸组之间总生存率有显著差异。与对照组（180 天）相比，叶酸缺乏组（174 天，P=0.56）和补充组（177 天，P=0.13）的中位生存时间没有统计学差异。与对照组相比，叶酸缺乏组的红细胞叶酸水平与膳食叶酸摄入量呈正相关（P=0.023、0.0096 和 0.0006，分别为缺乏组与对照组、对照组与补充组、缺乏组与补充组）。根据叶酸组评估背根神经节（DRG）、臂丛和坐骨神经。与对照组相比，叶酸缺乏组的 DRG 明显增大（P=0.044），但其他组没有统计学差异。根据叶酸状态，臂丛或坐骨神经增大无显著差异。
