闭胸犬心肌高能磷酸代谢：动物模型的建立
Myocardial high energy phosphate metabolism in closed chest dog: creation of an animal model.
作者信息
Osbakken M, Ligeti L, Clark B J, Bolinger L, Subramanian H, Schnall M, Leigh J, Chance B
出版信息
Magn Reson Med. 1986 Oct;3(5):801-7. doi: 10.1002/mrm.1910030516.
PMID:3784896
Abstract
A chronic closed chest dog model was developed to study myocardial metabolism with NMR spectroscopy. Cardiac windows were surgically created in 10 dogs by removal of two ribs and accompanying skeletal muscle. Marlex mesh was sewn between the two exposed ribs, and fascia and skin were closed. 31P spectra were obtained using a surface coil placed into the surgically created pouch and using routine NMR pulsing techniques.
摘要
建立了一种慢性闭胸犬模型，用于通过核磁共振波谱研究心肌代谢。通过切除两根肋骨及附着的骨骼肌，在10只犬身上手术制造心脏窗口。将Marlex网缝在两根暴露的肋骨之间，然后缝合筋膜和皮肤。使用置于手术制造的袋囊中 的表面线圈并采用常规核磁共振脉冲技术获取³¹P波谱。
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