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职业接触石棉粉尘的女性患癌风险

[Risk of cancer in women occupationally exposed to asbestos dust].

作者信息

Szeszenia-Dabrowska N, Wilczyńska U, Szymczak W

出版信息

Med Pr. 1986;37(4):243-9.

PMID:3784903
Abstract

In order to estimate the risk of death due to cancer in those occupationally exposed to asbestos dust, 1190 women--workers of an asbestos producing plant--employed for at least 3 months during 1945-1973, were examined. The cohort availability for 31 December 1981 was 89.6%. The risk was analyzed basing on the standardized mortality ratio (SMR) calculated by the man-years method. The reference group was that of the general population of women in Poland. In the test cohort, 136 deaths occurred (SMR = 93.3), in this 46 were caused by malignant tumours (SMR = 162.0), 25 by malignant tumours of the digestive organs and peritoneum (SMR = 226.9), 13 by malignant tumours of the liver and pancreas (SMR = 360.9). The mortality due to the above mentioned causes was significantly higher than that of the general population. In the subcohort of women employed during 1945-1955 selected for the very high concentration of asbestos dust 95 deaths occurred in this period (SMR = 111.1). Significantly higher than in the reference population was mortality of: malignant tumours totally (32 deaths, SMR = 206.1), malignant tumours of the digestive organs and peritoneum (20 deaths. SMR = 311.0), and malignant tumours of the liver and pancreas (12 deaths, SMR = 541.5).

摘要

为了评估职业接触石棉粉尘人群的癌症死亡风险,对1190名女性——一家石棉生产厂的工人——进行了检查,她们在1945年至1973年期间至少工作了3个月。截至1981年12月31日,该队列的可获得率为89.6%。基于人年法计算的标准化死亡比(SMR)对风险进行了分析。参照组为波兰女性总人口。在测试队列中,发生了136例死亡(SMR = 93.3),其中46例由恶性肿瘤导致(SMR = 162.0),25例由消化器官和腹膜恶性肿瘤导致(SMR = 226.9),13例由肝脏和胰腺恶性肿瘤导致(SMR = 360.9)。上述原因导致的死亡率显著高于总人口。在1945年至1955年期间受雇、石棉粉尘浓度极高的女性亚队列中,这一时期发生了95例死亡(SMR = 111.1)。以下死亡率显著高于参照人群:恶性肿瘤总计(32例死亡,SMR = 206.1)、消化器官和腹膜恶性肿瘤(20例死亡,SMR = 311.0)以及肝脏和胰腺恶性肿瘤(12例死亡,SMR = 541.5)。

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