Botta M, Magnani C, Terracini B, Bertolone G P, Castagneto B, Cocito V, DeGiovanni D, Paglieri P
Casale Monferrato Hospital, Italy.
Cancer Detect Prev. 1991;15(6):445-7.
A cohort study is presented on the mortality of blue-collar workers in an asbestos-cement production plant that has been operating since 1907. Use of both crocidolite and chrysotile is reported. The cohort includes 2608 men and 759 women who were employed in the plant on Jan. 1, 1950 and those who started to work between 1950 and 1980. Follow-up was terminated on April 15, 1986 with 97.9% traced. Expected deaths were estimated from the age- and sex-specific regional mortality rates for the years 1969 to 1981. The data have been analyzed for the period 1964 to 1986 based on person-years at risk: 43,000 for men and 14,494 for women. A statistically significant increase was found in both sexes for mortality from all causes. From 1964 to 1986, 728 men died from all causes (608 expected), 275 with cancer at any site (158 expected) 110 with lung cancer (41 expected), 28 with pleural tumors (1 expected) and 85 with asbestosis (less than 1 expected). Corresponding figures for women were--all causes: 136 deaths versus 102 expected; all cancers: 79 verses 32 expected; lung cancer: 7 versus 2 expected; pleural tumor: 15 versus 0 expected and asbestosis: 4 versus 0 expected. Deaths from digestive tract cancer were in excess only among women (18 observed versus 10 expected, p less than 0.01). No excess was found for deaths from laryngeal cancer. Standardized mortality rates (SMR) for lung cancer among males showed a clear increase in direct relationship with length of follow-up. SMR according to length of employment were 234 for length 10 to 19 years, 363 for 20 to 29 years, and 256 for 30 years or longer (p less than 0.05 and lower).
本文呈现了一项关于一家自1907年起运营的石棉水泥生产厂蓝领工人死亡率的队列研究。报告了该厂青石棉和温石棉的使用情况。该队列包括1950年1月1日受雇于该厂的2608名男性和759名女性，以及1950年至1980年间开始工作的人员。随访于1986年4月15日结束，追踪率为97.9%。根据1969年至1981年按年龄和性别划分的地区死亡率估计预期死亡人数。基于风险人年数对1964年至1986年期间的数据进行了分析：男性为43,000人年，女性为14,494人年。发现男女所有原因导致的死亡率均有统计学显著增加。1964年至1986年期间，728名男性死于所有原因（预期为608人），275人死于任何部位癌症（预期为158人），110人死于肺癌（预期为41人），28人死于胸膜肿瘤（预期为1人），85人死于石棉沉着病（预期少于1人）。女性的相应数据为：所有原因：136人死亡，预期为102人；所有癌症：79人，预期为32人；肺癌：7人，预期为2人；胸膜肿瘤：15人，预期为0人；石棉沉着病：4人，预期为0人。仅女性消化道癌死亡人数超过预期（观察到18人，预期为10人，p<0.01）。未发现喉癌死亡人数超过预期。男性肺癌的标准化死亡率（SMR）与随访时间呈明显的直接增加关系。根据就业时长的SMR分别为：就业10至19年为234，20至29年为363，30年及以上为256（p<0.05及更低）。
