Department of Cardiovascular Surgery, Arkansas Children's Hospital, 1 Children's Way, Little Rock, AR 72202, USA.
Division of Research, Alabama College of Osteopathic Medicine, 445 Health Sciences Blvd, Dothan, AL 36303, USA.
Future Cardiol. 2024;20(13):719-728. doi: 10.1080/14796678.2024.2404775. Epub 2024 Sep 27.
Partial heart transplantation (PHT) has emerged as a new treatment strategy to correct unrepairable heart valve dysfunction in pediatric patients. PHT selectively replaces the dysfunctional components of the recipient's heart and spares the native ventricles. As a result, the transplant biology of PHTs differs from heart transplants. Notably, donor hearts that are unsuitable for whole heart transplantation can be used, graft preservation can be prolonged and immunosuppression levels can be lowered. These nuances of PHT transplant biology have important implications for organizational aspects of PHT clinical application.
部分心脏移植（PHT）已成为一种新的治疗策略，用于纠正儿科患者无法修复的心脏瓣膜功能障碍。PHT 选择性地替换受体心脏的功能障碍部分，并保留原生心室。因此，PHT 的移植生物学与心脏移植不同。值得注意的是，可以使用不适合进行全心脏移植的供心，可以延长移植物保存时间，并降低免疫抑制水平。这些 PHT 移植生物学的细微差别对 PHT 临床应用的组织方面具有重要意义。
