Bock Eduardo, Pfleging Wilhelm, Tada Dayane, Macedo Erenilda, Premazzi Nathalia, Sá Rosa, Solheid Juliana, Besser Heino, Andrade Aron
Laboratory of Bioengineering and Biomaterials, Federal Institute of Technology in Sao Paulo (IFSP), Sao PauloBrazil.
Center of Engineering in Circulatory Assistance, Institute Dante Pazzanese of Cardiology (IDPC), Sao Paulo, Brazil.
BME Front. 2022 Jul 13;2022:9782562. doi: 10.34133/2022/9782562. eCollection 2022.
. Laser-treated surfaces for ventricular assist devices. . This work has scientific impact since it proposes a biofunctional surface created with laser processing in bioinert titanium. . Cardiovascular diseases are the world's leading cause of death. An especially debilitating heart disease is congestive heart failure. Among the possible therapies, heart transplantation and mechanical circulatory assistance are the main treatments for its severe form at a more advanced stage. The development of biomaterials for ventricular assist devices is still being carried out. Although polished titanium is currently employed in several devices, its performance could be improved by enhancing the bioactivity of its surface. . Aiming to improve the titanium without using coatings that can be detached, this work presents the formation of laser-induced periodic surface structures with a topology suitable for cell adhesion and neointimal tissue formation. The surface was modified by femtosecond laser ablation and cell adhesion was evaluated by using fibroblast cells. . The results indicate the formation of the desired topology, since the cells showed the appropriate adhesion compared to the control group. Scanning electron microscopy showed several positive characteristics in the cells shape and their surface distribution. The results obtained with different topologies point that the proposed LIPSS would provide enhanced cell adhesion and proliferation. . The laser processes studied can create new interactions in biomaterials already known and improve the performance of biomaterials for use in ventricular assist devices.
用于心室辅助装置的激光处理表面。这项工作具有科学影响力，因为它提出了一种通过在生物惰性钛中进行激光加工而创建的生物功能表面。心血管疾病是全球主要的死亡原因。一种特别使人衰弱的心脏病是充血性心力衰竭。在可能的治疗方法中，心脏移植和机械循环辅助是其晚期严重形式的主要治疗方法。心室辅助装置生物材料的研发仍在进行中。尽管目前几种装置中使用的是抛光钛，但通过增强其表面的生物活性可以提高其性能。为了在不使用可能脱落的涂层的情况下改进钛，这项工作展示了具有适合细胞粘附和新内膜组织形成拓扑结构的激光诱导周期性表面结构的形成。通过飞秒激光烧蚀对表面进行改性，并使用成纤维细胞评估细胞粘附情况。结果表明形成了所需的拓扑结构，因为与对照组相比，细胞显示出适当的粘附。扫描电子显微镜显示细胞形状及其表面分布具有几个积极特征。不同拓扑结构获得的结果表明，所提出的激光诱导周期性表面结构将提供增强的细胞粘附和增殖。所研究的激光工艺可以在已知的生物材料中产生新的相互作用，并改善用于心室辅助装置的生物材料的性能。
