Zolan M E, Pukkila P J
Mol Cell Biol. 1986 Jan;6(1):195-200. doi: 10.1128/mcb.6.1.195-200.1986.
We examined the inheritance of 5-methylcytosine residues at a centromere-linked locus in the basidiomycete Coprinus cinereus. Although methylated and unmethylated tracts were inherited both mitotically and meiotically the lengths of these tracts were variable. This variation was not confined to any one phase of the life cycle of the organism, and it usually involved the simultaneous de novo methylation of at least four HpaII-MspI sites. We also found that the higher levels of methylation at this locus were transmitted through meiosis, regardless of the level of methylation of the homologous chromosome.
我们研究了担子菌灰盖鬼伞中着丝粒连锁位点处5-甲基胞嘧啶残基的遗传情况。尽管甲基化和非甲基化片段在有丝分裂和减数分裂中均能遗传，但其长度是可变的。这种变异并不局限于该生物体生命周期的任何一个阶段，并且通常涉及至少四个HpaII-MspI位点的同时从头甲基化。我们还发现，该位点较高水平的甲基化通过减数分裂传递，而与同源染色体的甲基化水平无关。
