Department of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250012, China.
Biomed Pharmacother. 2023 Dec;168:115713. doi: 10.1016/j.biopha.2023.115713. Epub 2023 Oct 16.
Metabolic reprogramming is a common hallmark of cancers and involves alterations in many metabolic pathways during tumor initiation and progression. However, the cancer-specific modulation of metabolic reprogramming requires further elucidation. Succinylation, a newly identified protein posttranslational modification (PTM), participates in many cellular processes by transferring a succinyl group to a residue of the target protein, which is related to various pathological disorders including cancers. In recent years, there has been a gradual increase in the number of studies on the regulation of tumors by protein succinylation. Notably, accumulating evidence suggests that succinylation can mediate cancer cell metabolism by altering the structure or activity of metabolism-related proteins and plays vital roles in metabolic reprogramming. Furthermore, some antitumor drugs have been linked to succinylation-mediated tumor-associated metabolism. To better elucidate lysine succinylation mediated tumor metabolic reprogramming, this review mainly summarizes recent studies on the regulation and effects of protein succinylation in tumors, focusing on the metabolic regulation of tumorigenesis and development, which will provide new directions for cancer diagnosis as well as possible therapeutic targets.
代谢重编程是癌症的一个共同标志，涉及肿瘤发生和进展过程中许多代谢途径的改变。然而，代谢重编程的癌症特异性调节需要进一步阐明。琥珀酰化是一种新发现的蛋白质翻译后修饰（PTM），通过将琥珀酰基转移到靶蛋白的残基上来参与许多细胞过程，与包括癌症在内的各种病理紊乱有关。近年来，关于蛋白质琥珀酰化调节肿瘤的研究逐渐增多。值得注意的是，越来越多的证据表明，琥珀酰化可以通过改变与代谢相关的蛋白质的结构或活性来介导癌细胞代谢，在代谢重编程中发挥重要作用。此外，一些抗肿瘤药物与琥珀酰化介导的肿瘤相关代谢有关。为了更好地阐明赖氨酸琥珀酰化介导的肿瘤代谢重编程，本综述主要总结了近年来关于肿瘤中蛋白质琥珀酰化的调节和作用的研究，重点关注肿瘤发生和发展的代谢调节，这将为癌症诊断以及可能的治疗靶点提供新的方向。
