外周血浆中长链非编码 RNA ANRIL 的增加是稳定型心绞痛的一个指标。
An increase in a long noncoding RNA ANRIL in peripheral plasma is an indicator of stable angina.
机构信息
Department of Histology and Embryology, School of Basic Medical Sciences, Central South University, China; Department of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, China.
School of Forensic, School of Basic Medical Sciences, Central South University, China.
出版信息
Clinics (Sao Paulo). 2023 Oct 16;78:100289. doi: 10.1016/j.clinsp.2023.100289. eCollection 2023.
INTRODUCTION
Stable angina develops during physical activity or stress, and it is typically an aspect of Coronary Heart Disease (CHD) that can lead to arrhythmia, heart failure and even sudden death. ANRIL, an Antisense Noncoding RNA gene in the INK4 Locus, is associated with multiple disorders including CHD; however, expressional levels of ANRIL in between patients with stable angina and myocardial infarction, one of the acute coronary syndrome, have not been clarified yet.
METHODS
The authors enrolled 62 patients with myocardial infarction and 59 with stable angina before primary percutaneous coronary intervention, as well as 48 healthy volunteers. Their peripheral blood was collected for analysis of ANRIL and cardiac troponin I, a traditional diagnostic index of CHD by real-time PCR.
RESULTS
The data showed that ANRIL is a better diagnostic indicator than cardiac troponin I in patients with stable angina and that the levels of ANRIL are higher in patients with stable angina than those with the myocardial infarction.
DISCUSSION
The levels of ANRIL in peripheral plasma could be used as a good biomarker for stable angina.
简介
稳定型心绞痛发生于体力活动或应激时，通常是冠心病（CHD）的一个方面，可导致心律失常、心力衰竭甚至猝死。位于INK4 基因座的反义非编码 RNA 基因 ANRIL 与多种疾病相关，包括 CHD；然而，在稳定型心绞痛和心肌梗死（急性冠状动脉综合征之一）患者之间，ANRIL 的表达水平尚未阐明。
方法
作者纳入了 62 例心肌梗死患者和 59 例稳定型心绞痛患者，以及 48 例健康志愿者。他们的外周血用于通过实时 PCR 分析 ANRIL 和心脏肌钙蛋白 I，后者是 CHD 的传统诊断指标。
结果
数据显示，ANRIL 是稳定型心绞痛患者比心脏肌钙蛋白 I 更好的诊断指标，且稳定型心绞痛患者的 ANRIL 水平高于心肌梗死患者。
讨论
外周血浆中的 ANRIL 水平可用作稳定型心绞痛的良好生物标志物。
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