长链非编码RNA：动脉粥样硬化的最新进展
Long Noncoding RNA: Recent Updates in Atherosclerosis.
作者信息
Li Hao, Zhu Hongming, Ge Junbo
机构信息
1. Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
2. Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
出版信息
Int J Biol Sci. 2016 Jun 7;12(7):898-910. doi: 10.7150/ijbs.14430. eCollection 2016.
Long noncoding RNAs belong to a class of noncoding RNAs longer than 200 nucleotides with the epigenetic regulation potential. As a novel molecular regulator, lncRNAs are often dysregulated in various pathological conditions and display multiple functions in a wide range of biological processes. Given that recent studies have indicated that lncRNAs are involved in atherosclerosis-related smooth muscle cell, endothelial cell, macrophage and lipid metabolism regulation, it is pertinent to understand the potential function of lncRNAs in atherosclerosis development. This review will highlight the recent updates of lncRNAs in atherogenesis and also discuss their potential roles as novel therapeutic targets.
长链非编码RNA属于一类长度超过200个核苷酸且具有表观遗传调控潜力的非编码RNA。作为一种新型分子调节因子，长链非编码RNA在各种病理条件下常常失调，并在广泛的生物学过程中发挥多种功能。鉴于最近的研究表明长链非编码RNA参与动脉粥样硬化相关的平滑肌细胞、内皮细胞、巨噬细胞和脂质代谢调节，了解长链非编码RNA在动脉粥样硬化发展中的潜在功能是很有必要的。这篇综述将重点介绍长链非编码RNA在动脉粥样硬化发生过程中的最新进展，并讨论它们作为新型治疗靶点的潜在作用。
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