Department of Structural Heart Disease, National Center for Cardiovascular Disease, China & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
National Health Commission Key Laboratory of Cardiovascular Regeneration Medicine, Beijing, China.
Eur Heart J Qual Care Clin Outcomes. 2024 May 22;10(3):203-215. doi: 10.1093/ehjqcco/qcad063.
To increase the comprehensive understanding of trends in the burden of cardiovascular disease (CVD) attributable to low physical activity in the Western Pacific Region.
Based on data from the Global Burden of Disease study for the years 1990-2019, an age-period-cohort analysis was conducted to investigate trends in CVD-related mortality attributable to low physical activity in the Western Pacific Region and associations with age, period, and birth cohort. We also used joinpoint regression analysis to identify the periods with the most substantial changes. The results show that, the Western Pacific Region witnessed a substantial increase in CVD deaths attributable to low physical activity, accompanied by a rise in all-age CVD-related mortality. However, the age-standardized death rate was lower in the region than the global level, highlighting the importance of considering the age composition of CVD burden in the region. Countries with higher socio-demographic index (SDI) levels exhibited lower mortality than those with lower SDI levels. The longitudinal analysis using the age-period-cohort model indicated an overall improvement in CVD-related mortality attributable to low physical activity in the region, but with differences between sexes and CVD subtypes. Specific period in which CVD-related mortality decreased significantly was 2011-16, for the average annual percentage change for the period was -0.69%.
The study highlights the significance of addressing low physical activity as a modifiable risk factor for CVD burden in the Western Pacific Region. Further research is essential to understand the factors contributing to inter-country variations, sex disparities, and CVD subtypes distinctions.
提高对西太平洋地区低体力活动导致心血管疾病（CVD）负担趋势的综合认识。
基于 1990-2019 年全球疾病负担研究的数据，采用年龄-时期-队列分析方法，调查西太平洋地区低体力活动导致的 CVD 相关死亡率的变化趋势，并探讨其与年龄、时期和出生队列的关系。同时，我们还采用联合回归分析确定变化最显著的时期。结果表明，西太平洋地区因低体力活动导致的 CVD 死亡人数显著增加，同时全年龄段 CVD 相关死亡率也有所上升。然而，该地区的年龄标准化死亡率低于全球水平，这突显了在该地区考虑 CVD 负担的年龄构成的重要性。社会人口指数（SDI）较高的国家的死亡率低于 SDI 较低的国家。采用年龄-时期-队列模型的纵向分析表明，该地区因低体力活动导致的 CVD 相关死亡率总体上有所改善，但存在性别和 CVD 亚型的差异。CVD 相关死亡率显著下降的具体时期是 2011-16 年，该时期的年均百分比变化为-0.69%。
本研究强调了在西太平洋地区将低体力活动作为可改变的 CVD 负担风险因素进行干预的重要性。进一步的研究对于了解导致国家间差异、性别差异和 CVD 亚型差异的因素至关重要。
