Luo Yanfang, Liu Jinguang, Zeng Jinshan, Pan Hailin
Department of Cardiology, Huizhou Municipal People's Hospital, Huizhou, 516001, PR China.
Am J Prev Cardiol. 2024 Feb 6;17:100633. doi: 10.1016/j.ajpc.2024.100633. eCollection 2024 Mar.
BACKGROUND: Low physical activity is a major risk factor for cardiovascular diseases (CVDs). This study aimed to estimate the global, regional, national, and sex-age-specific burden of CVDs attributed to low physical activity from 1990 to 2019. METHODS: We leveraged data from the Global Burden of Disease Study 2019 to compute the number of fatalities, disability-adjusted life years (DALYs), age-adjusted mortality rates (ASMR), and age-adjusted DALY rates (ASDR) attributed to CVDs resulting from low physical activity. Furthermore, we scrutinized the trends and correlations of these metrics in connection with the socio-demographic index (SDI) across 21 regions and 204 countries and territories. RESULTS: The global deaths and DALYs due to CVDs caused by low physical activity increased from 371,042.96 [95 % UI: 147,621.82-740,490] and 6,282,524.95 [95 % UI: 2,334,970.61-13,255,090.08] in 1990 to 639,174.92 [95 % UI: 272,011.34-1,216,528.4] and 9,996,080.17 [95 % UI: 4,130,111.16-20,323,339.89] in 2019, respectively. The corresponding ASMR and ASDR decreased from 12.55 [95 % UI: 5.12-24.23] and 181.64 [95 % UI: 71.59-374.01] in 1990 to 8.6 [95 % UI: 3.68-16.28] and 127.52 [95 % UI: 53.07-256.55] in 2019, respectively. Deaths and DALYs attributed to low physical activity were initially higher in males but shifted to females after 70-74 age group. Both genders had increasing death rates, peaking at 80-84 age group. Most CVDs deaths and DALYs number are caused by ischemic heart disease. The highest burden of CVDs attributed to low physical activity was observed in North Africa and the Middle East. The lowest burden was observed in Oceania and High-income Asia Pacific. There was a distinctive 'n-shape' relationship between the regional SDI and the ASDR of CVDs attributed to low physical activity from 1990 to 2019. CONCLUSION: The global impact of CVDs stemming from low physical activity remains substantial and demonstrates substantial regional disparities. As individuals age, this burden becomes more prominent, particularly among females. Efficacious interventions are imperative to promote physical activity and mitigate the risk of CVDs across diverse populations and regions.
背景：身体活动不足是心血管疾病（CVD）的主要危险因素。本研究旨在估计1990年至2019年全球、区域、国家以及按性别和年龄划分的因身体活动不足导致的心血管疾病负担。 方法：我们利用《2019年全球疾病负担研究》的数据，计算因身体活动不足导致的心血管疾病的死亡人数、伤残调整生命年（DALY）、年龄标准化死亡率（ASMR）和年龄标准化DALY率（ASDR）。此外，我们审视了这些指标在21个地区以及204个国家和地区与社会人口指数（SDI）相关的趋势和相关性。 结果：1990年因身体活动不足导致的心血管疾病的全球死亡人数和DALY分别为371,042.96[95%UI：147,621.82 - 740,490]和6,282,524.95[95%UI：2,334,970.61 - 13,255,090.08]，到2019年分别增至639,174.92[95%UI：272,011.34 - 1,216,528.4]和9,996,080.17[95%UI：4,130,111.16 - 20,323,339.89]。相应的ASMR和ASDR分别从1990年的12.55[95%UI：5.12 - 24.23]和181.64[95%UI：71.59 - 374.01]降至2019年的8.6[95%UI：3.68 - 16.28]和127.52[95%UI：53.07 - 256.55]。因身体活动不足导致的死亡人数和DALY最初男性高于女性，但在70 - 74岁年龄组之后转向女性。两性的死亡率均呈上升趋势，在80 - 84岁年龄组达到峰值。大多数心血管疾病死亡人数和DALY由缺血性心脏病导致。因身体活动不足导致的心血管疾病负担在北非和中东地区最高。在大洋洲和高收入亚太地区负担最低。1990年至2019年，区域SDI与因身体活动不足导致的心血管疾病的ASDR之间存在独特的“n形”关系。 结论：因身体活动不足导致的心血管疾病的全球影响仍然很大，并显示出显著的地区差异。随着个体年龄增长，这种负担变得更加突出，尤其是在女性中。必须采取有效的干预措施，以促进身体活动并降低不同人群和地区的心血管疾病风险。
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