何种类型和剂量的体力活动最适合预防结直肠癌？

What is the optimal type and dose of physical activity for colorectal cancer prevention?

机构信息

Newcastle University Centre for Cancer, Newcastle University, Newcastle Upon Tyne, UK; School of Biomedical, Nutritional and Sport Sciences, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK.

出版信息

Best Pract Res Clin Gastroenterol. 2023 Oct;66:101841. doi: 10.1016/j.bpg.2023.101841. Epub 2023 May 24.

DOI:10.1016/j.bpg.2023.101841

PMID:37852708

Abstract

Epidemiological evidence shows that higher levels of physical activity reduce the relative risk of colon cancer by up to 20%. To design optimal physical activity interventions for primary prevention, it is important to understand how the specific characteristics of physical activity (type, intensity, overall volume) influence the magnitude of colon cancer risk reduction. Improving our understanding of the underlying biological mechanisms will also help to manipulate physical activity characteristics to precisely target mechanisms of action and identify populations most likely to benefit. This review synthesizes the best available evidence to explore how the type and dose of physical activity moderate the protective effect of physical activity on colon cancer.

摘要

流行病学证据表明，较高水平的身体活动可将结肠癌的相对风险降低多达 20%。为了设计针对初级预防的最佳身体活动干预措施，了解身体活动（类型、强度、总量）的具体特征如何影响结肠癌风险降低的程度非常重要。提高我们对潜在生物学机制的理解也将有助于操纵身体活动特征，以精确针对作用机制，并确定最有可能受益的人群。本综述综合了现有最佳证据，以探讨身体活动的类型和剂量如何调节身体活动对结肠癌的保护作用。