Department of Pathology, Harbin Medical University, Harbin, 150081, China; Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia; Department of Physiology, Harbin Medical University, Harbin, 150081, China.
Crit Rev Oncol Hematol. 2022 Feb;170:103578. doi: 10.1016/j.critrevonc.2022.103578. Epub 2022 Jan 7.
Numerous epidemiological studies indicate that physical activity has a protective effect against colon cancer development and progression. Further, the relevant biological mechanisms where physical activity or exercise may improve survival have also been initially examined. In this review, we provide an overview of the epidemiological evidence to date which comprises 16 cohort studies of the effects of physical activity on colon cancer outcomes including cancer recurrence, cancer-specific and overall survival. Moreover, we present four potential mechanisms involving shear pressure, systemic milieu alteration, extracellular vesicles, and immune function by which physical activity and exercise may favorably impact colon cancer. Research currently in progress will provide definitive evidence of survival benefits resulting from exercise and future work will help clarify the role of targeted exercise and the relevant mechanisms involved.
大量的流行病学研究表明，身体活动对结肠癌的发生和发展具有保护作用。此外，身体活动或运动改善生存的相关生物学机制也已初步研究。在这篇综述中，我们概述了迄今为止的流行病学证据，其中包括 16 项关于身体活动对结肠癌结局（包括癌症复发、癌症特异性和总体生存）影响的队列研究。此外，我们提出了四个潜在的机制，包括剪切压力、全身环境改变、细胞外囊泡和免疫功能，身体活动和运动可能通过这些机制对结肠癌产生有利影响。目前正在进行的研究将提供运动带来的生存获益的确切证据，未来的工作将有助于阐明靶向运动的作用和相关机制。
