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评估育龄期女性正常子宫的关键参数。

Assessment of key parameters of normal uterus in women of reproductive age.

机构信息

Medical Center of Diagnosis and Treatment for Cervical Diseases, Obstetrics and Gynecology Hospital of Fudan University, No.419 Fangxie Road, Shanghai, 200011, China.

Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

出版信息

Sci Rep. 2023 Oct 18;13(1):17794. doi: 10.1038/s41598-023-44489-6.

DOI:10.1038/s41598-023-44489-6
PMID:37852992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10584964/
Abstract

Currently, the precise and detailed anatomical data of the normal uterus, especially the myometrium thickness in various parts of the uterus, are lacking. This study aims to provide normal references for uterine size in healthy reproductive-aged Chinese women to facilitate the application of hysteroscopic surgery. A total of 298 women of reproductive age with normal uterine were included. Parity was significantly correlated with uterine measurements (P < 0.05), and age impacted several measurements (P < 0.05). At each uterine site examined, the myometrium was thinner in nulliparous women than in parous or primiparous women (P < 0.001). Similarly, the extrauterine measurements for parous or primiparous women were larger than those for nulliparous women. Weight affected some external measurements but not myometrial thicknesses, while height did not affect uterine measurements (P > 0.05). There was a positive correlation between body mass index (BMI) and extrauterine measurements as well as myometrial thickness (P < 0.05). The mathematical model of the uterine size for women of reproductive age was constructed stratified by parity. The study is the first to provide a detailed statistical description of the accurate anatomical parameters of the uterus in Chinese reproductive-aged women and has great significance for improving the safety and effectiveness of hysteroscopic surgery for patients.

摘要

目前,正常子宫的精确和详细解剖数据,特别是子宫各部位的肌层厚度,尚不清楚。本研究旨在为中国生育年龄健康妇女的子宫大小提供正常参考,以方便宫腔镜手术的应用。共纳入 298 名生育年龄正常的妇女。产次与子宫测量值显著相关(P<0.05),年龄影响几个测量值(P<0.05)。在检查的每个子宫部位,初产妇的子宫肌层比经产妇或初产妇薄(P<0.001)。同样,经产妇或初产妇的子宫外测量值大于初产妇。体重影响一些外部测量值,但不影响肌层厚度,而身高不影响子宫测量值(P>0.05)。体重指数(BMI)与子宫外测量值和肌层厚度呈正相关(P<0.05)。根据产次分层建立了生育年龄妇女子宫大小的数学模型。该研究首次详细描述了中国生育年龄妇女子宫的精确解剖参数,对提高宫腔镜手术治疗患者的安全性和有效性具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2d8/10584964/ecdbf12beebd/41598_2023_44489_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2d8/10584964/fda6b5325e59/41598_2023_44489_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2d8/10584964/74a691498c8a/41598_2023_44489_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2d8/10584964/ecdbf12beebd/41598_2023_44489_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2d8/10584964/fda6b5325e59/41598_2023_44489_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2d8/10584964/74a691498c8a/41598_2023_44489_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2d8/10584964/ecdbf12beebd/41598_2023_44489_Fig3_HTML.jpg

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Medicine (Baltimore). 2018 Aug;97(34):e12068. doi: 10.1097/MD.0000000000012068.
2
Are 3D ultrasound and office hysteroscopy useful for the assessment of uterine cavity after late foetal loss?三维超声和门诊宫腔镜检查对评估晚期胎儿丢失后的子宫腔是否有用?
J Gynecol Obstet Hum Reprod. 2018 May;47(5):183-186. doi: 10.1016/j.jogoh.2018.02.002. Epub 2018 Feb 21.
3
Septum resection for women of reproductive age with a septate uterus.
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Front Med (Lausanne). 2025 Apr 28;12:1563888. doi: 10.3389/fmed.2025.1563888. eCollection 2025.
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Age-related uterine changes and its association with poor reproductive outcomes: a systematic review and meta-analysis.年龄相关性子宫变化及其与不良生殖结局的关系:系统评价和荟萃分析。
Reprod Biol Endocrinol. 2024 Nov 30;22(1):152. doi: 10.1186/s12958-024-01323-6.
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