Clinical School of Obstetrics and Gynecology Center, Tianjin Medical University, Tianjin, China.
Department of Gynecological Oncology, Tianjin Central Hospital Gynecology Obstetrics, No. 156, Nansanma Road, Nankai District, Tianjin, 300000, China.
Sci Rep. 2023 Oct 18;13(1):17790. doi: 10.1038/s41598-023-44681-8.
Cuproptosis is a unique type of cell death that may influence tumour formation by targeting lipoylated tricarboxylic acid cycle proteins. Solute carrier family 31 member 1 (SLC31A1), an important copper transporter, influences dietary copper absorption in the cell membrane. However, various SLC31A1 properties in pan-cancer profiles remain unknown. This study investigated the role of SLC31A1 in human malignancies and analysed its prognostic value. Raw data were obtained from The Cancer Genome Atlas database and processed using numerous internet databases, including UALCAN, GEPIA, cBioPortal, TIMER2.0, and Human Protein Atlas. SLC31A1 expression was found to be elevated in cervical, endometrial, and breast cancers compared to that in normal tissues, but reduced in clear cell renal cell carcinoma, liver hepatocellular carcinoma, and lung adenocarcinoma. Furthermore, SLC31A1 expression was strongly associated with overall survival and disease-free survival in several cancers. SLC31A1 gene mutations and methylations were identified in 33 cancers. SLC31A1 expression was positively correlated with immune cells in immune infiltration data. Single-cell sequencing revealed that SLC31A1 may play key roles in DNA repair, DNA damage, and proliferation. These findings may lead to better understanding of SLC31A1 in pan-cancer profiles and suggest that SLC31A1 could be a viable predictive biomarker, particularly in gynaecological cancers.
铜死亡是一种独特的细胞死亡方式，可能通过靶向脂酰化三羧酸循环蛋白影响肿瘤形成。溶质载体家族 31 成员 1（SLC31A1）是一种重要的铜转运蛋白，影响细胞膜中膳食铜的吸收。然而，在泛癌症图谱中，各种 SLC31A1 特性仍然未知。本研究调查了 SLC31A1 在人类恶性肿瘤中的作用，并分析了其预后价值。原始数据来自癌症基因组图谱数据库，并使用包括 UALCAN、GEPIA、cBioPortal、TIMER2.0 和 Human Protein Atlas 在内的多个互联网数据库进行处理。与正常组织相比，SLC31A1 在宫颈癌、子宫内膜癌和乳腺癌中的表达升高，但在透明细胞肾细胞癌、肝肝癌和肺腺癌中降低。此外，SLC31A1 表达与几种癌症的总生存期和无病生存期密切相关。在 33 种癌症中发现了 SLC31A1 基因突变和甲基化。SLC31A1 表达与免疫浸润数据中的免疫细胞呈正相关。单细胞测序表明，SLC31A1 可能在 DNA 修复、DNA 损伤和增殖中发挥关键作用。这些发现可能有助于更好地理解 SLC31A1 在泛癌症图谱中的作用，并表明 SLC31A1 可能是一种可行的预测生物标志物，特别是在妇科癌症中。
