Solute carrier family 31 member 1 () encodes a protein that functions as a homotrimer for the uptake of dietary copper. As a vital member of the cuproptosis gene family, it plays an essential role in both normal tissues and tumors. In this study, we analyzed across human cancer types to gain a better understanding of 's role in cancer development. We searched for information using online databases to analyze, systematically and comprehensively, the role of in tumors. Amongst nine cancer types, the expression of was significantly different between tumors and normal tissues. According to further analysis, pancreatic cancer had the highest mutation rate of the gene, and the methylation levels of the gene were significantly reduced in seven tumors. The expression of is also linked to the infiltration of tumors by immune cells, the expression of immune checkpoint genes, and immunotherapy markers (TMB and MSI), suggesting that may be of particular relevance in immunotherapy. This thorough analysis of across different types of cancer gives us a clear and comprehensive insight into its role in causing cancer on a systemic level.