Psychology Department, University of New Mexico, Logan Hall, MSC03 2220, 87131, Albuquerque, NM, Mexico.
Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, Mexico.
Cogn Affect Behav Neurosci. 2024 Apr;24(2):292-301. doi: 10.3758/s13415-023-01134-z. Epub 2023 Oct 18.
We recently advanced a rodent homologue for the reward-specific, event-related potential component observed in humans known as the Reward Positivity. We sought to determine the cortical source of this signal in mice to further test the nature of this homology. While similar reward-related cortical signals have been identified in rats, these recordings were all performed in cingulate gyrus. Given the value-dependent nature of this event, we hypothesized that more ventral prelimbic and infralimbic areas also contribute important variance to this signal. Depth probes assessed local field activity in 29 mice (15 males) while they completed multiple sessions of a probabilistic reinforcement learning task. Using a priori regions of interest, we demonstrated that the depth of recording in the cortical midline significantly correlated with the size of reward-evoked delta band spectral activity as well as the single trial correlation between delta power and reward prediction error. These findings provide important verification of the validity of this translational biomarker of reward responsiveness, learning, and valuation.
我们最近提出了一个啮齿动物同源物，用于研究人类中观察到的与奖励相关的事件相关电位成分，即奖励正波。我们试图确定这种信号在小鼠中的皮质源，以进一步测试这种同源性的本质。虽然在大鼠中已经识别出类似的与奖励相关的皮质信号，但这些记录都是在扣带回皮层中进行的。鉴于这种事件的价值依赖性，我们假设更腹侧的前扣带回和下前扣带回区域也对这种信号有重要的影响。深度探针评估了 29 只小鼠（15 只雄性）在完成多次概率强化学习任务时的局部场活动。使用先验的感兴趣区域，我们证明了皮质中线的记录深度与奖励诱发的δ波段光谱活动的大小以及δ功率和奖励预测误差之间的单次试验相关性显著相关。这些发现为这个奖励反应性、学习和估值的转化生物标志物的有效性提供了重要的验证。
