Törnberg S A, Holm L E, Carstensen J M, Eklund G A
N Engl J Med. 1986 Dec 25;315(26):1629-33. doi: 10.1056/NEJM198612253152601.
We studied the risk of colorectal cancer in relation to serum cholesterol and beta-lipoprotein in more than 92,000 Swedish subjects less than 75 years old. The cohort was examined between 1963 and 1965 and followed by means of the Swedish Cancer Register until 1979. During this period, 528 colon cancers and 311 rectal cancers developed. A positive association was observed between the serum cholesterol level and the risk of rectal cancer among men (P less than 0.05), with a relative risk of 1.65 in men with levels greater than or equal to 276 mg per deciliter (7.1 mmol per liter). An association was also observed between the serum beta-lipoprotein level and the risk of rectal cancer among men (P less than 0.05). When cholesterol and beta-lipoprotein levels were considered together, they were associated with both rectal and colon cancer in men. The relative risk in men with both cholesterol greater than or equal to 250 mg per deciliter (6.5 mmol per liter) and beta-lipoprotein greater than or equal to 12 units (2.2 g per liter) was 1.62 for colon cancer (95 percent confidence interval, 1.18 to 2.22) and 1.70 for rectal cancer (1.18 to 2.44). Similar trends were observed in women, although they were not statistically significant.
我们研究了92000多名75岁以下瑞典受试者的血清胆固醇和β脂蛋白与结直肠癌风险之间的关系。该队列在1963年至1965年间接受检查，并通过瑞典癌症登记处进行随访直至1979年。在此期间，发生了528例结肠癌和311例直肠癌。在男性中，血清胆固醇水平与直肠癌风险之间存在正相关（P<0.05），胆固醇水平大于或等于276毫克/分升（7.1毫摩尔/升）的男性相对风险为1.65。在男性中，血清β脂蛋白水平与直肠癌风险之间也存在关联（P<0.05）。当同时考虑胆固醇和β脂蛋白水平时，它们与男性的直肠癌和结肠癌均有关联。胆固醇大于或等于250毫克/分升（6.5毫摩尔/升）且β脂蛋白大于或等于12单位（2.2克/升）的男性患结肠癌的相对风险为1.62（95%置信区间为1.18至2.22），患直肠癌的相对风险为1.70（1.18至2.44）。在女性中也观察到了类似的趋势，尽管在统计学上不显著。
