血清铁蛋白

Serum ferritin.

作者信息

Worwood M

出版信息

CRC Crit Rev Clin Lab Sci. 1979;10(2):171-204. doi: 10.3109/10408367909147133.

Abstract

(1) Brief introduction to iron metabolism and the biochemistry of ferritin. (2) Early studies of circulating ferritin. (3) Methods for measuring serum ferritin concentrations -- immunoradiometric, radioimmuno- and enzyme-linked immuno assays based on liver or spleen ferritin -- an evaluation of these techniques. (4) Serum ferritin concentrations in normal subjects -- definition of normality -- relationship between storage iron and serum ferritin concentrations -- changes during development from birth to old age -- iron deficiency -- variability of serum ferritin concentration -- evaluation of use of ferritin assay for assessment of storage iron levels. (5) Serum ferritin concentrations in disease -- hemochromatosis -- secondary iron overload -- liver damage -- infection and chronic disease -- cancer. (6) Assay of serum ferritin with antibodies to ferritins other than liver or spleen -- ferritinemia and cancer. (7) Properties of serum ferritin -- molecular weight -- iron content -- isoelectric focusing patterns -- carbohydrate content -- immunological properties. (8) Physiology of circulating ferritin -- release of ferritin from tissues -- origin of circulating ferritin -- clearance from the plasma -- iron and protein turnover. (9) Summary -- factors influencing serum ferritin concentrations and clinical use of ferritin estimations.

摘要

(1) 铁代谢与铁蛋白生物化学简介。(2) 循环铁蛋白的早期研究。(3) 血清铁蛋白浓度的测量方法——基于肝或脾铁蛋白的免疫放射测定法、放射免疫测定法和酶联免疫测定法——对这些技术的评估。(4) 正常受试者的血清铁蛋白浓度——正常范围的定义——储存铁与血清铁蛋白浓度的关系——从出生到老年发育过程中的变化——缺铁——血清铁蛋白浓度的变异性——评估铁蛋白测定法用于评估储存铁水平的情况。(5) 疾病状态下的血清铁蛋白浓度——血色素沉着症——继发性铁过载——肝损伤——感染与慢性病——癌症。(6) 用针对肝或脾以外铁蛋白的抗体测定血清铁蛋白——铁蛋白血症与癌症。(7) 血清铁蛋白的特性——分子量——铁含量——等电聚焦图谱——碳水化合物含量——免疫学特性。(8) 循环铁蛋白的生理学——铁蛋白从组织中的释放——循环铁蛋白的来源——从血浆中的清除——铁与蛋白质周转。(9) 总结——影响血清铁蛋白浓度的因素及铁蛋白测定的临床应用。