Department of Medical Services and Techniques, Vocational School of Health Services, Adiyaman University, Adiyaman, Turkey.
Department of Medical Biology, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey.
Gene. 2023 Jan 30;851:147012. doi: 10.1016/j.gene.2022.147012. Epub 2022 Oct 29.
For a long time, scientists believed that only changes or mutations in protein-coding genes were responsible for the onset and development of cancer. However, the discovery of non-coding RNAs has revolutionized our understanding of tumor biology. Now, we are aware that non-coding RNA molecules have a higher influence on cancer biology than previously thought. The discovery of non-coding RNAs also presented several challenges because they are relatively unstable under laboratory conditions and can lead to false-positive and false-negative results in expression analysis. Therefore, variation analysis may provide more accurate results for understanding the role and impact of these molecules in cancer biology. Accordingly, in the present comprehensive review, we aimed to review and discuss current knowledge on non-coding RNA alterations linked to the development and progression of oral malignancies. Collectively, variations of non-coding RNA molecules seem to have great impact in the development and progression of oral cancers.
长期以来，科学家们一直认为只有蛋白质编码基因的变化或突变才会导致癌症的发生和发展。然而，非编码 RNA 的发现彻底改变了我们对肿瘤生物学的理解。现在，我们意识到非编码 RNA 分子对癌症生物学的影响比之前认为的要大。非编码 RNA 的发现也带来了一些挑战，因为它们在实验室条件下相对不稳定，并且可能导致表达分析中的假阳性和假阴性结果。因此，变异分析可能为理解这些分子在癌症生物学中的作用和影响提供更准确的结果。因此，在本综述中，我们旨在回顾和讨论与口腔恶性肿瘤发生和进展相关的非编码 RNA 改变的最新知识。总的来说，非编码 RNA 分子的变异似乎对口腔癌的发展和进展有重大影响。
