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伊维菌素对遗传性癫痫鸡的抗惊厥作用。

Anticonvulsant effects of ivermectin in genetically-epileptic chickens.

作者信息

Crichlow E C, Mishra P R, Crawford R D

出版信息

Neuropharmacology. 1986 Oct;25(10):1085-8. doi: 10.1016/0028-3908(86)90154-1.

DOI:10.1016/0028-3908(86)90154-1
PMID:3785577
Abstract

In genetically-photosensitive epileptic chickens, the anti-parasitic agent ivermectin, at 1.0 and 5.0 mg/kg, decreased or prevented seizures induced by intermittent photic stimulation without any side-effects on the central nervous system. The latency and duration of this anti-convulsant effect was dose-dependent. When combined with diazepam, ivermectin prolonged the anti-convulsant action of diazepam.

摘要

在遗传性光敏性癫痫鸡中,抗寄生虫药伊维菌素以1.0毫克/千克和5.0毫克/千克的剂量,可减少或预防由间歇性光刺激诱发的癫痫发作,且对中枢神经系统无任何副作用。这种抗惊厥作用的潜伏期和持续时间呈剂量依赖性。当与地西泮联合使用时,伊维菌素可延长地西泮的抗惊厥作用。

相似文献

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Anticonvulsant effects of ivermectin in genetically-epileptic chickens.伊维菌素对遗传性癫痫鸡的抗惊厥作用。
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Clinical signs of ivermectin toxicity and the efficacy of antigabaergic convulsants as antidotes for ivermectin poisoning in epileptic chickens.伊维菌素中毒的临床症状以及抗γ-氨基丁酸能惊厥剂作为癫痫鸡伊维菌素中毒解毒剂的疗效。
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Epileptiform seizures in domestic fowl. VII. Plasma phenytoin concentrations and anticonvulsant activity.家禽的癫痫样发作。VII. 血浆苯妥英浓度与抗惊厥活性。
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