2023 年 2 月至 8 月，意大利北部新型 NDM 产生克隆 CC147 迅速传播。
Rapid spread of a novel NDM-producing clone of CC147, Northern Italy, February to August 2023.
机构信息
Microbiology and Virology Unit, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy.
Specialization School of Microbiology and Virology, University of Pavia, Pavia, Italy.
出版信息
Euro Surveill. 2023 Oct;28(42). doi: 10.2807/1560-7917.ES.2023.28.42.2300522.
New Delhi metallo-beta-lactamase (NDM)-producing () ST147 caused a large multi-hospital outbreak in Italy from 2018 to 2021. We describe a new ST6668 NDM-producing clone, belonging to CC147, which rapidly spread across hospitals in the Pavia province (Northern Italy) from February to August 2023. Genomic analyses revealed that ST6668 is different from ST147 and fast evolving. As shown here, genomic surveillance programmes are useful for tracking the spread of new clones with reduced susceptibility to most antibiotics.
新德里金属-β-内酰胺酶（NDM）产生的 （）ST147 导致 2018 年至 2021 年意大利发生了大规模多医院暴发。我们描述了一种新的 ST6668 NDM 产生的 克隆，属于 CC147，它从 2023 年 2 月到 8 月迅速在意大利北部帕维亚省的医院之间传播。基因组分析表明，ST6668 与 ST147 不同，并且进化迅速。如本文所示，基因组监测计划对于跟踪具有降低对大多数抗生素敏感性的新克隆的传播非常有用。
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