Aberg J A, Demers L M, Romano P J, Tenser R B
Department of Pathology, Penn State College of Medicine, Hershey, Pennsylvania 17033.
J Clin Lab Anal. 1990;4(4):246-50. doi: 10.1002/jcla.1860040403.
Peripheral blood monocytes have been implicated in the immune reactions that accompany demyelination in patients with multiple sclerosis (MS). We measured prostaglandin E2 (PGE2) and thromboxane B2 (TxB2) release from peripheral monocytes exposed in vitro to complement. Our studies suggest that there is a significantly higher production of PGE2 in monocytes from patients with chronic progressive MS than in those with exacerbation or remitting MS and healthy controls. No significant differences in TxB2 release were noted between the three groups.
外周血单核细胞与多发性硬化症（MS）患者脱髓鞘相关的免疫反应有关。我们测量了体外暴露于补体的外周单核细胞中前列腺素E2（PGE2）和血栓素B2（TxB2）的释放。我们的研究表明，慢性进展型MS患者的单核细胞中PGE2的产生显著高于病情加重型或缓解型MS患者及健康对照。三组之间TxB2释放没有显著差异。
