Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.
Faculty of Medicine, Ege University, Izmir, Turkey.
Pathol Res Pract. 2023 Nov;251:154853. doi: 10.1016/j.prp.2023.154853. Epub 2023 Oct 6.
Fibrosis is a pathological wound-healing mechanism that results by the overactivation of fibroblasts. Fibrosis can become obstructive and deleterious during regeneration of various body tissues including cardiac muscle. This ultimately results in the development of cardiac fibrosis, characterized by an excessive buildup of extracellular matrix proteins. Thus, it could lead to arrhythmias and heart failure which creates a leading public health burden worldwide. MiRNAs are small non-coding RNAs with great potential for diagnostic and therapeutic purposes. Mounting evidence indicates that miRNAs are involved in the deregulation of tissue homeostasis during myocardial fibrosis. For instance, miRNAs that are implicated in the regulation of TGF-beta signaling pathway have been reported to be significantly altered in myocardial fibrosis. Accordingly, in this comprehensive review, we discuss and highlight recent available data on the role of miRNAs during myocardial fibrosis, providing valuable insights into the miRNA modulation of cardiac fibrosis and miRNAs targets that can be used in the future therapeutic interventions to cardiac fibrosis.
纤维化是一种病理性的创伤愈合机制，是由成纤维细胞的过度激活引起的。在包括心肌在内的各种身体组织的再生过程中，纤维化可能会变得具有阻塞性和有害性。这最终导致心肌纤维化的发展，其特征是细胞外基质蛋白的过度积累。因此，它可能导致心律失常和心力衰竭，这在全球范围内造成了主要的公共卫生负担。miRNAs 是具有巨大诊断和治疗潜力的小非编码 RNA。越来越多的证据表明，miRNAs 参与了心肌纤维化过程中组织内稳态的失调。例如，据报道，参与 TGF-β信号通路调节的 miRNAs 在心肌纤维化中发生了显著改变。因此，在本综述中，我们讨论并强调了 miRNA 在心肌纤维化过程中的作用的最新可用数据，为 miRNA 对心脏纤维化的调节以及未来可用于心脏纤维化治疗干预的 miRNA 靶点提供了有价值的见解。
