Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Key Laboratory of Organ Transplantation, Ministry of Education, and NHC Key Laboratory of Organ Transplantation, Wuhan 430030, China.
Genes (Basel). 2022 Aug 4;13(8):1390. doi: 10.3390/genes13081390.
Cardiac fibrosis is a significant global health problem associated with almost all types of heart disease. Extensive cardiac fibrosis reduces tissue compliance and contributes to adverse outcomes, such as cardiomyocyte hypertrophy, cardiomyocyte apoptosis, and even heart failure. It is mainly associated with pathological myocardial remodeling, characterized by the excessive deposition of extracellular matrix (ECM) proteins in cardiac parenchymal tissues. In recent years, a growing body of evidence demonstrated that microRNAs (miRNAs) have a crucial role in the pathological development of cardiac fibrosis. More than sixty miRNAs have been associated with the progression of cardiac fibrosis. In this review, we summarized potential miRNAs and miRNAs-related regulatory mechanisms for cardiac fibrosis and discussed the potential clinical application of miRNAs in cardiac fibrosis.
心肌纤维化是一个全球性的重大健康问题，几乎与所有类型的心脏病都有关。广泛的心肌纤维化降低了组织顺应性，并导致不良后果，如心肌细胞肥大、心肌细胞凋亡，甚至心力衰竭。它主要与病理性心肌重构有关，其特征是心肌实质组织中细胞外基质（ECM）蛋白的过度沉积。近年来，越来越多的证据表明 microRNAs（miRNAs）在心肌纤维化的病理发展中起着关键作用。有六十多种 miRNAs 与心肌纤维化的进展有关。在这篇综述中，我们总结了潜在的 miRNAs 及其与心肌纤维化相关的调节机制，并讨论了 miRNAs 在心肌纤维化中的潜在临床应用。
