Kanagawa Dental University, Kanagawa, Japan.
Department of Radiology, University of Kentucky College of Medicine, Lexington, KY, United States of America.
J Radiol Prot. 2023 Nov 10;43(4). doi: 10.1088/1361-6498/ad04f0.
The benefits of biomedical research involving humans are well recognised, along with the need for conformity to international standards of science and ethics. When human research involves radiation imaging procedures or radiotherapy, an extra level of expert review should be provided from the point of view of radiological protection. The relevant publication of the International Commission for Radiological Protection (ICRP) is now three decades old and is currently undergoing an update. This paper aims to provoke discussions on how the risks of radiation dose and the benefits of research should be assessed, using a case study of diagnostic radiology involving volunteers for whom there is no direct benefit. Further, the paper provides the current understanding of key concepts being considered for review and revision-such as the dose constraint and the novel research methods on the horizon, including radiation biology and epidemiology. The analysis revisits the perspectives described in the ICRP Publication 62, and considers the recent progress in both radiological protection ethics and medical research ethics.
人们充分认识到涉及人体的生物医学研究的益处，同时也需要符合科学和伦理的国际标准。当人体研究涉及放射影像程序或放射治疗时，应从放射防护的角度提供额外的专家审查。国际放射防护委员会（ICRP）的相关出版物已有三十年的历史，目前正在进行更新。本文旨在通过一个涉及志愿者的诊断放射学案例研究，探讨如何评估辐射剂量的风险和研究的益处，该案例研究中志愿者没有直接受益。此外，本文还介绍了正在考虑进行审查和修订的关键概念的最新理解，例如剂量约束和新出现的研究方法，包括放射生物学和流行病学。该分析重新审视了 ICRP 出版物 62 中描述的观点，并考虑了放射防护伦理学和医学研究伦理学的最新进展。
