Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Japan.
Department of Bioscience and Biotechnology, Faculty of Bioenvironmental Sciences, Kyoto University of Advanced Science, Kameoka, Japan.
FEBS Lett. 2024 Jan;598(1):48-58. doi: 10.1002/1873-3468.14760. Epub 2023 Nov 3.
The discovery of microautophagy, the direct engulfment of cytoplasmic material by the lysosome, dates back to 1966 in a morphological study of mammalian cells by Christian de Duve. Since then, studies on microautophagy have shifted toward the elucidation of the physiological significance of the process. However, in contrast to macroautophagy, studies on the molecular mechanisms of microautophagy have been limited. Only recent studies revealed that ATG proteins involved in macroautophagy are also operative in several types of microautophagy and that ESCRT proteins, responsible for the multivesicular body pathway, play a central role in most microautophagy processes. In this review, we summarize our current knowledge on the function of ATG and ESCRT proteins in microautophagy.
微自噬，溶酶体直接吞噬细胞质物质的发现，可以追溯到 1966 年 Christian de Duve 对哺乳动物细胞的形态学研究。自那时以来，对微自噬的研究已经转向阐明该过程的生理意义。然而，与巨自噬不同，对微自噬分子机制的研究受到限制。最近的研究表明，参与巨自噬的 ATG 蛋白也在几种类型的微自噬中起作用，并且负责多泡体途径的 ESCRT 蛋白在大多数微自噬过程中发挥核心作用。在这篇综述中，我们总结了我们目前对 ATG 和 ESCRT 蛋白在微自噬中的功能的了解。
