Zhang Wen-Gang, Wu Qing-Zhen, Shao Bo-Zong
Department of Gastroenterology, General Hospital of the Chinese People's Liberation Army, Beijing, China.
Front Pharmacol. 2024 Sep 30;15:1444657. doi: 10.3389/fphar.2024.1444657. eCollection 2024.
Pancreatic diseases such as pancreatitis and pancreatic cancer represent significant health challenges characterized by high mortality rates and limited survival durations. Autophagy, a crucial cellular catabolic process, has emerged as a focal point in understanding various pathological conditions, spanning inflammation-related disorders to malignant neoplasms. This comprehensive review aims to elucidate the biological intricacies of autophagy and its pivotal roles within two extensively researched pancreatic diseases, namely pancreatitis and pancreatic cancer, drawing upon recent scholarly contributions. The discussion will delve into the nuanced mechanisms underlying autophagy's involvement in these diseases, shedding light on its potential as a therapeutic target. Furthermore, the review will explore cutting-edge therapeutic interventions leveraging autophagy regulation for managing pancreatitis and pancreatic cancer. Through this analysis, we endeavor to offer novel insights into the pathophysiology of pancreatic disorders and contribute to the development of innovative therapeutic modalities in this challenging clinical domain.
胰腺炎和胰腺癌等胰腺疾病是重大的健康挑战，其特点是死亡率高、生存期有限。自噬是一种关键的细胞分解代谢过程，已成为理解从炎症相关疾病到恶性肿瘤等各种病理状况的焦点。本综述旨在借鉴近期学术成果，阐明自噬的生物学复杂性及其在两种广泛研究的胰腺疾病——胰腺炎和胰腺癌中的关键作用。讨论将深入探讨自噬参与这些疾病的细微机制，揭示其作为治疗靶点的潜力。此外，本综述还将探索利用自噬调节来治疗胰腺炎和胰腺癌的前沿治疗干预措施。通过这一分析，我们致力于为胰腺疾病的病理生理学提供新的见解，并为这一具有挑战性的临床领域中创新治疗方法的发展做出贡献。
