Department of Gastroenterology, First Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100853, China.
World J Gastroenterol. 2024 Sep 28;30(36):4014-4020. doi: 10.3748/wjg.v30.i36.4014.
Gastrointestinal disorders encompass a spectrum of conditions affecting various organs within the digestive system, such as the esophagus, stomach, colon, rectum, pancreas, liver, small intestine, and bile ducts. The role of autophagy in the etiology and progression of gastrointestinal diseases has garnered significant attention. This paper seeks to evaluate the impact and mechanisms of autophagy in gastrointestinal disorders by synthesizing recent research findings. Specifically, we delve into inflammation-related gastrointestinal conditions, including ul-cerative colitis, Crohn's disease, and pancreatitis, as well as gastrointestinal cancers such as esophageal, gastric, and colorectal cancers. Additionally, we provide commentary on a recent publication by Chang in the . Our objective is to offer fresh perspectives on the mechanisms and therapeutic approaches for these gastrointestinal ailments. This review aims to offer new perspectives on the mechanisms and therapeutic strategies for gastrointestinal disorders by critically analyzing relevant publications. As discussed, the role of autophagy in gastrointestinal diseases is complex and, at times, contentious. To harness the full therapeutic potential of autophagy in treating these conditions, more in-depth research is imperative.
胃肠道疾病包括一系列影响消化系统内各种器官的疾病，如食管、胃、结肠、直肠、胰腺、肝脏、小肠和胆管。自噬在胃肠道疾病的病因和进展中的作用引起了广泛关注。本文旨在通过综合最新研究成果，评估自噬在胃肠道疾病中的作用和机制。具体而言，我们深入探讨了与炎症相关的胃肠道疾病，包括溃疡性结肠炎、克罗恩病和胰腺炎，以及胃肠道癌症，如食管癌、胃癌和结直肠癌。此外，我们还对 Chang 在 上的一篇最新论文进行了评论。我们的目标是为这些胃肠道疾病的机制和治疗方法提供新的视角。
这篇综述通过批判性地分析相关文献，旨在为胃肠道疾病的机制和治疗策略提供新的视角。如前所述，自噬在胃肠道疾病中的作用是复杂的，有时甚至存在争议。为了充分发挥自噬在治疗这些疾病中的治疗潜力，需要进行更深入的研究。
