NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai, China.
NYU Shanghai, Shanghai, China.
Nat Neurosci. 2023 Nov;26(11):1942-1952. doi: 10.1038/s41593-023-01461-x. Epub 2023 Oct 19.
Frontal and parietal cortex are implicated in economic decision-making, but their causal roles are untested. Here we silenced the frontal orienting field (FOF) and posterior parietal cortex (PPC) while rats chose between a cued lottery and a small stable surebet. PPC inactivations produced minimal short-lived effects. FOF inactivations reliably reduced lottery choices. A mixed-agent model of choice indicated that silencing the FOF caused a change in the curvature of the rats' utility function (U = V). Consistent with this finding, single-neuron and population analyses of neural activity confirmed that the FOF encodes the lottery value on each trial. A dynamical model, which accounts for electrophysiological and silencing results, suggests that the FOF represents the current lottery value to compare against the remembered surebet value. These results demonstrate that the FOF is a critical node in the neural circuit for the dynamic representation of action values for choice under risk.
额顶皮层和顶叶皮层参与经济决策，但它们的因果作用尚未得到验证。在这里，我们在大鼠在有提示的彩票和小而稳定的确定赌注之间进行选择时，沉默了额前导向场（FOF）和顶后皮质（PPC）。PPC 失活产生了最小的短期影响。FOF 失活可靠地减少了彩票选择。选择的混合代理模型表明，沉默 FOF 导致大鼠效用函数（U=V）的曲率发生变化。与这一发现一致，对神经活动的单个神经元和群体分析证实，FOF 在每次试验中都对彩票值进行编码。一个可以解释电生理和沉默结果的动力学模型表明，FOF 代表当前的彩票值，以便与记忆中的确定赌注值进行比较。这些结果表明，FOF 是神经回路中用于风险下行动值动态表示的关键节点。
