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本文引用的文献

1
Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer's disease mice.淀粉样蛋白-β（Aβ）免疫疗法诱导的微出血与阿尔茨海默病小鼠中血管周围巨噬细胞的激活和外周单核细胞的募集有关。
Mol Neurodegener. 2023 Aug 30;18(1):59. doi: 10.1186/s13024-023-00649-w.
2
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.一种与限制阿尔茨海默病发展相关的独特小胶质细胞类型。
Cell. 2017 Jun 15;169(7):1276-1290.e17. doi: 10.1016/j.cell.2017.05.018. Epub 2017 Jun 8.
3
Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions.具有完全消除的免疫效应功能的新型人IgG1和IgG4 Fc工程抗体。
Protein Eng Des Sel. 2016 Oct;29(10):457-466. doi: 10.1093/protein/gzw040. Epub 2016 Aug 29.
4
Matrix Metalloproteinase in Blood-Brain Barrier Breakdown in Dementia.基质金属蛋白酶与痴呆症中血脑屏障的破坏
J Alzheimers Dis. 2016;49(4):893-903. doi: 10.3233/JAD-150759.
5
An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.一种效应器降低的抗β-淀粉样蛋白（Aβ）抗体，具有独特的 Aβ 结合特性，可促进 Aβ 的神经保护和胶质细胞吞噬作用。
J Neurosci. 2012 Jul 11;32(28):9677-89. doi: 10.1523/JNEUROSCI.4742-11.2012.
6
Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence.抗 Aβ 免疫治疗后基质金属蛋白酶的激活；对微出血发生的影响。
J Neuroinflammation. 2011 Sep 9;8:115. doi: 10.1186/1742-2094-8-115.
7
Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup.淀粉样蛋白相关成像异常在淀粉样蛋白修饰治疗试验中的研究：来自阿尔茨海默病协会研究圆桌工作组的建议。
Alzheimers Dement. 2011 Jul;7(4):367-85. doi: 10.1016/j.jalz.2011.05.2351.
8
Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice.去糖基化抗淀粉样β抗体可消除老年淀粉样前体蛋白转基因小鼠的认知缺陷并减少实质淀粉样蛋白，同时将血管影响降至最低。
J Neurosci. 2006 May 17;26(20):5340-6. doi: 10.1523/JNEUROSCI.0695-06.2006.
9
Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.免疫疗法加剧淀粉样前体蛋白转基因小鼠中脑淀粉样血管病相关的微出血取决于抗体对沉积形式的β淀粉样蛋白的识别。
J Neurosci. 2005 Jan 19;25(3):629-36. doi: 10.1523/JNEUROSCI.4337-04.2005.
10
Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration.颅内注射抗β淀粉样蛋白抗体后，小胶质细胞激活有助于β淀粉样蛋白斑块的清除。
Neurobiol Dis. 2004 Feb;15(1):11-20. doi: 10.1016/j.nbd.2003.09.015.

Mechanisms of ARIA: is it time to focus on the unique immune environment of the neurovascular unit?

作者信息

Foley Kate E, Weekman Erica M, Wilcock Donna M

机构信息

Stark Neurosciences Research Institute, Indiana University School of Medicine, 320 W 15th St, Indianapolis, IN, 46202, USA.

Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

出版信息

Mol Neurodegener. 2023 Oct 20;18(1):76. doi: 10.1186/s13024-023-00667-8.

DOI:10.1186/s13024-023-00667-8
PMID:37858154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10588106/
Abstract
摘要